Mood Systems Balance, by Douglas Laboratories, is a blend of beneficial ingredients targeted to balance the body’s systems correlated with mood and a sense of well-being.

Saffron extract, Rhodiola, Longvida® Optimized Curcumin, chromium and berberine support the physiology of the body that can affect mood and neurotransmitters such cognition, HPA axis physiology, blood glucose regulation and healthy digestion.* Functions: Glycemic control, healthy digestion and balanced hypothalamic-pituitary- adrenal (HPA) axis functions are 3 key functions to help optimize one’s mood.* Several plant-based ingredients along with chromium have been shown to support these system functions.* Saffron has been traditionally used as a calmative, mood support botanical, contributing to better digestion of food. Crocus sativa L. is native to the Middle East, particularly Spain. Animal studies show the compounds safranal and crocin found in the saffron stigma may exert effects on mood by balancing levels of dopamine, norepinephrine, and serotonin.* Saffron has been studied in six human clinical trials analyzing HAM-D scores (Hamilton Rating Scale) over 6-8 weeks, with meta-analysis showing this botanical to have clear and beneficial mood support properties.* Rhodiola is a well-studied adaptogenic herb that supports many body systems, and can impact cardiovascular and cognitive health, especially as it relates to energy, mood, and sleep.* One six week trial assessed the efficacy of 340-680 mg of standardized rhodiola extract and found notable benefits compared to placebo.* It is believed the changes in monoamine levels are a result of compounds contained in Rhodiola rosea inhibiting the activity of the enzymes involved in the degradation of norepinephrine and serotonin, specifically monoamine oxidase and catechol- O-methyltransferase. It is also believed that Rhodiola rosea facilitates the transport of neurotransmitters within the brain.* Curcumin is considered the active component in the Indian spice called turmeric. With a reputation spanning thousands of years, turmeric’s mood benefits stem from its direct impact on brain chemistry.* It is hypothesized that curcumin supports mood by inhibiting the monoamine oxidase enzyme and modulating the release of serotonin and dopamine neurotransmitters. Longvida® Optimized Curcumin is a bioavailable form of curcumin utilizing SLCP™ technology, Solid Lipid Curcumin Particles, to aid in absorption and deliver brain-permeable free curcumin. A randomized, double-blind, placebo-controlled trial examined the effects of 400 mg Longvida® on cognitive function, mood and blood biomarkers in healthy aging adults. Working memory as well as mood, measured as calmness, contentedness and fatigue induced by psychological stress, were significantly supported following use of Longvida Optimized Curcumin.* Berberine is a naturally occurring alkaloid known to help digestion, support blood sugar metabolism, and balance mood.* Berberine modulates gut microbiota, a key player in mood support.* It also supports central nervous system activities, particularly the ability to inhibit monoamine oxidase-A. Animal studies have shown berberine’s ability to support mood, possibly through modulation of the sigma 1 receptor.* Human studies also show its ability to both support insulin action as well as digestive function.* The essential trace element chromium is a component of glucose tolerance factor, a complex molecule in the body used to balance insulin levels and maintain already healthy blood sugar.* Chromium’s mechanism may also exist in its ability to activate brain serotonin. In a small, placebo controlled trial chromium has demonstrated mood benefits in 70% of subjects.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results may vary.

Label Information

Supplement Facts
Serving Size: 2 Vegetarian Capsules
Servings Per Container: 30
Amount Per Serving%DV
Chromium (as Chromium Dinicocysteinate†400 mcg333%
Rhodiola rosea root Extract (standardized to 3% rosavins)340 mg*
Berberine HCI250 mg*
LONGVIDA® Optimized Curcumin Extract200 mg*
(from Curcuma longa root)  
Saffron Extract (Crocus sativus L, stigmas)(standardized to 2% safranal)15 mg*
*Daily value not established

†Zychrome® brand chromium dinicocysteinate. Trademark of InterHealth N.I. Longvida® is patent protected under EP 1993365, other patents pending, and is a registered trademark of Verdure Sciences Inc.

  • Suggested Use:

    Adults take 2 capsules, 1-2 times daily, or as directed by a healthcare professional.

  • Storage: Keep out of reach of children. For optimal storage conditions, store in a cool, dry place. (59°-77°F/15°-25°C) (35-65% relative humidity) Tamper resistant package, do not use if outer seal is missing.
  • Contraindications: If you are pregnant, nursing, have any health condition or taking any medication, consult your health care practitioner before using this product.
  • Other Ingredients: Hydroxypropyl methylcellulose (capsule), cellulose, phosphatidylcholine (from soy), stearic acid, ascorbyl palmitate, and silica.
  • Contains No: Yeast, wheat, gluten, milk/dairy, corn, sodium, sugar, starch, artificial coloring, artificial preservatives or genetically modified organisms (GMOs).