EnZym-Complete/DPP-IV II with Isogest is Kirkman’s second generation version of Enzym-Complete/DPPIV. It contains all the enzymes present in Enzym-Complete/DPPIV plus Isogest. The presence of Isogest gives this product the equivalent activity of the isomaltase fraction of the sucrase/isomaltase enzyme found in the human digestive system.

Individuals currently using Enzym-Complete/DPPIV™ who are getting partial results and still need some improvement or individuals using other enzymes who are not completely satisfied with the results should try EnZym-Complete/DPP-IV™ II with Isogest® formula. Isogest® has the ability to split isomaltose into two molecules of glucose and to split palatinose into one molecule of glucose and one molecule of fructose. The result of including this new enzyme is better, more complete carbohydrate digestion. Currently, no other enzyme product can offer this added activity. The human intestinal tract contains seven enzymes that split dietary disaccharides into free monosaccharides. Until now, commercially available enzyme products contained enzyme ingredients that had the activity of only some of these disaccharidase enzymes. One in particular, however, sucrase-isomaltase complex, was only partially represented in these products. Invertase is present in these products to hydrolyze sucrose to yield glucose and fructose, and to hydrolyze other complex sugars that contain fructose, so it acts as a sucrase enzyme. The isomaltase fraction of that human enzyme is not represented because there is no commercially available form of isomaltase in the world. The importance of this missing enzyme fraction was confirmed in January 2004 by R. Kushak, Ph.D., and T. Buie, M.D., of Massachusetts General Children’s Hospital in an intestinal biopsy study involving 100 children with special requirements and sensitivities. The study showed that 60% of these patients had weak lactase activity and 25-45% had weak isomaltase/palatinase activity, which substantiated their special dietary need for an enzyme providing isomaltase/palatinase activity. This study provided the impetus for Kirkman® to search for an enzyme that had isomaltase/palatinase activity. Kirkman® found that enzyme and trademarked it Isogest® Physicians and parents who evaluated products containing Kirkman’s Isogest® reported the following:

  • less bloating
  • more regular bowel habits
  • less constipation
  • more normal stools
  • better overall digestion with less discomfort
  • firmer stools
  • less gas
  • less diarrhea
  • less sensitivity to dairy and grains
  • less odorous bowel movements

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Label Information

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving%DV*
Peptidase25,000 HUT*
Acid Fast Protease (3.0)50 SAPU*
Transglucosidase (Isogest®)33 mg*
Bromelain640,000 FCCPU*
Papain1,000,000 FCCPU*
Glucoamylase32 AGU*
Lactase500 ALU*
Phytase5 FTU*
Alpha-galactosidase25 GaIU*
Invertase (Sucrase)200 SU*
Cellulase100 CU*
Xylanase50 XU*
Alpha Amylase50 DU*
Protease (6.0)87.5 HUT*
Diastase1.3 DP*
n-zimes PA® Containing:55 mg*
Lipase1,375 FIP*
Protease11,000 HUT*
Amylase412.5 DU*
* Daily Values Not Established
  • Suggested Use:

    One capsule at the beggining of every meal or as directed by a physician.

  • Storage: Store in a cool, dry place and tightly capped. Keep away from children.
  • Contraindications: Do not allow the powder in the capsules to get into the eye or contact the skin. Contains soy.
  • Other Ingredients: plant cellulose, maltodextrin, water, microcrystalline cellulose.
  • Contains No: sugar, wheat, casein, gluten, milk, egg, yeast, gelatin, flavorings, colorings, peanuts, tree nuts or fish.