AMPK is an enzyme found in every cell in your body. But the natural, age-related decline in AMPK is a major cause of unwanted abdominal fat. And since studies show that increasing AMPK activity can actually encourage your cells to stop storing fat and start burning it for energy, Life Extension created AMPK Metabolic Activator.

Certain types of fat create more health concerns than others, and abdominal fat is one of the worst offenders. Belly fat is more than unsightly; it can also speed up natural aspects of the aging process throughout your body.1 That’s because abdominal fat can actually create compounds that can cause inflammation and oxidative stress.2

That’s where the AMPK enzyme comes in. Remember, AMPK doesn’t just promote a healthy weight – it actually targets abdominal fat, the type of adipose tissue we should try to avoid.

Increasing the levels and activity of the AMPK enzyme within your body tells your cells to stop storing fat, and start using it to create ATP – a compound that your body uses for cellular energy. And our new AMPK Metabolic Activator combines the citrus flavonoid hesperidin with ActivAMP® G. pentaphyllum extract, two natural ingredients that safely trigger AMPK.2,3 This unique enzyme then starts burning unwanted fat, particularly around your abdomen.4,5

In addition to reducing abdominal fat and activating AMPK, hesperidin helps inhibit circulating hsCRP levels, a major inflammatory factor.3 It also helps maintain already-healthy cholesterol levels and promotes healthy vascular function.


1. Bioorg Med Chem. 2011 Nov 1;19(21):6254-60.
2. Biotechnol Lett, 34: 1607-16
3. J Clin Endocrinol Metab. 96: E782-92.
4. Obesity, (Silver Spring), 22: 63-71.
5. Nutr J. 15:6, 2016.

Label Information

Supplement Facts
Serving Size: 1 vegetarian tablet
Servings Per Container: 30
Amount Per Serving %DV
Calcium (as calcium carbonate) 130 mg 10%
Hesperidin [from orange extract (fruit)] 500 mg **
ActivAMP® gynostemma extract (leaf) 450 mg **
** Daily Value not established
ActivAMP® is a registered trademark of Gencor.
  • Suggested Use: Take one 1 tablet daily, with or without food, or as recommended by a healthcare practitioner.
  • Storage: Store in a cool dry place. Keep out of reach of children.
  • Contraindications: When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. Do not exceed recommended dose.
  • Other Ingredients: Microcrystalline cellulose, stearic acid, croscarmellose sodium, hydroxypropyl cellulose, aqueous film coating (hypromellose, glycerin, purified water), silica, vegetable stearate.
  • Contains No: GMO's