Each vegetarian tablet of High Potency Optimized Folate by Life Extension provides 5,000 mcg of the metabolically active 5-MTHF form of folate.

Folate helps maintain homocysteine levels within the normal range,1 thereby promoting cardiovascular health.2 Folate also supports neurotransmitter synthesis-which in turn, helps maintain cognitive abilities.3 However, not everyone has sufficient activity of the enzyme required to convert folate to its biologically active form, 5-methyltetrahydrofolate, or 5-MTHF.4,5 For those whose homocysteine levels remain stubbornly high, the answer lies with the bioactive form of folate called 5-MTHF, which is up to seven times more bioavailable than ordinary folic acid.6 This unique compound requires no enzymatic conversion to become metabolically active6-providing maximum support for both cardiovascular and cognitive health. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results may vary.

Label Information

Supplement Facts
Serving Size: 1 Vegetarian Tablet
Servings Per Container: 30
Amount Per Serving%DV
Folate as [(6S)-5-Methyltetrahydrofolic acid, glucosamine salt]†5,000 mcg1250%

†Quatrefolic® is a registered trademark of Gnosis, S.p.A., Patent number 7,947,662.

  • Suggested Use:

    Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

  • Storage: Store in a cool dry place. Keep out of reach of children.
  • Contraindications: Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. Do not exceed recommended dose.
  • Other Ingredients: microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.
  • Contains No: GMO's.