Two non-GMO vegetarian tablets of Life Extension’s Immune Senescence Protection Formula™ taken daily provide comprehensive immune senescence protection.

As you age, your once-vigorous immune system begins to decline. An imbalance develops, involving a surplus of memory T cells and a deficit of naïve T cells. This produces a less-vigilant immune system-or immune senescence,1 which has been linked to problematic outcomes in normal aging.2 Life Extension® researchers have developed an innovative formula that now provides three potent ingredients designed to work in a complementary fashion to help rebalance the major arms of the aging immune system. Immune Senescence Protection Formula™ now includes Pu-Erh tea extract-providing additional and unique protection for the aging immune system!

Pu-Erh Tea

The cultivation of Pu-Erh tea began over 2,000 years ago and was historically consumed by emperors to provide them with longevity. Pu-Erh tea is rich in polyphenols and other bioactive molecules, including theabrownins, a unique group of compounds developed during the post-fermentation process.3 Modern science has shown that Pu-Erh tea extract may support healthy bone marrow function, which helps to rebuild the peripheral immune cellular components.4 An animal study demonstrated that Pu-Erh tea extract supports immune balance by decreasing stimulatory IL-6 immune cells by a remarkable 43%, as well as increasing natural killer (NK) cells by 7% and naïve T-cells by 10%.4


Cistanche plant extract promotes development of naïve T cells and supports a reduced number of memory T cells, helping to balance the immune response.5 It also supports NK-cell activity-resulting in a 15% life span increase in animal research.5 In a human study, a supplement containing standardized Cistanche produced improved immune factors, including an 11.7% increase in NK-cell activity and a 20.2% improvement in the ratio of CD4 to CD8 cells-which is indicative of healthy, youthful immune function.6

Reishi Mushroom

Numerous Reishi mushroom components help reverse many factors of immune senescence.7 Reishi extracts boost the function of innate immune cells, the immune system’s first line of defense.7 The unique polysaccharides, triterpenes, and other constituents enhance the body’s hematopoietic stem cells, macrophages, and other crucial immune factors8,9-broadly supporting immune function and longevity.10 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results may vary.

Label Information

Supplement Facts
Serving Size: 2 Vegetarian Tablets
Servings Per Container: 30
Amount Per Serving%DV
Calcium (as calcium carbonate)175 mg18%
Reishi mushroom extract (fruit body) [std. to (13.5%) polysaccharides, (6%) triterpenes]980 mg**
Pu-erh tea extract (leaf) [providing polyphenols, theabrownin]650 mg**
Cistanche tubulosa extract (stem and leaf) [std. to (22%) echinacosides]210 mg**
Shell-broken reishi mushroom (spore)150 mg**
** Daily Value not established.

Each serving contains approximately 32.5 mg of caffeine (the amount found in about a 3/4 cup brewed green tea).

  • Suggested Use:

    Take two (2) tablets daily with food, or as recommended by a healthcare practitioner.

  • Storage: Store in a cool dry place. Keep out of reach of children.
  • Contraindications: When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. Do not exceed recommended dose.
  • Other Ingredients: microcrystalline cellulose, starch, croscarmellose sodium, stearic acid, aqueous film coating (hypromellose, glycerin, purified water), hydroxypropyl cellulose, maltodextrin, silica, vegetable stearate.
  • Contains No: GMO's