Fat cells (adipocytes) secrete a hormone called leptin that tells our brain we have eaten enough.(5) Leptin can also facilitate the breakdown of stored triglycerides in our adipocytes via the process of lipolysis. Heavy individuals have startlinglyhigh blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from putting on so many fat pounds.
An extract from an African mango called Irvingia gabonensis has been shown to help support leptin sensitivity in overweight people. In a recently published study,irvingiademonstrated beneficial effects upon leptin blood levels, followed by weight loss and inches off the waistline.(1,3) In addition tosupporting healthy leptin sensitivity, irvingia has demonstrated the following beneficial effects on key aspects of metabolism:
- Glycerol-3-phosphate dehydrogenase is an enzyme involved in the complex biochemical process that converts ingested starch and sugar calories to stored body fat. Irvingia has been shown in studies involving fat cells to reduce the activity ofglycerol-3-phosphate dehydrogenase,(3) which may help reduce the impact of starch and sugar calories on body fat.
- Scientific research on fat cells suggests that irvingia has alpha-amylase-inhibiting properties(2) which can help support a slowing of the rate of carbohydrate absorption from the intestines and a reduction of the caloric impact of starchy and sugary foods.(4)
- Adiponectin is a hormone involved in helping to maintain insulin sensitivity on the membranes of energy-producing cells. Big fat cells produceless adiponectin, and overweight people need to be especially concerned about maintaining healthy levels of adiponectin to support insulin sensitivity and metabolic fitness. Scientific data suggests that irvingia helps support healthy adiponectin levels.(1,3)
Based on impressive human clinical data that supports weight loss of over 20 pounds on average in 10 weeks,(3) this standalone formula of an African mango extract, Integra-Lean® Irvingia, can help promote optimal weight. This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary. References:
1. Lipids Health Dis. 2008 Nov 13;7:44. (35)
2. Ann Nutr Metab. 1993; 37(1):14-23.
3. Lipids Health Dis. 2009 Mar 2;8:7.
4. Lipids Health Dis. 2008 Mar 31;7:12.
5. Prog Histochem Cytochem. 2010 Sep;45(3):143-200.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.