Life Extension has identified certain compounds in Optimized Resveratrol with Synergistic Grape-Berry Actives that mimic calorie restriction’s ability to trigger youthful gene expression, the process by which genes transmit signals that slow certain aspects of aging. These compounds include trans-resveratrol (which researchers contend is the most active constituent), whole grape extract, quercetin, plus certain compounds found in berries, including trans-pterostilbene and now fisetin.
Findings from published scientific literature indicate that resveratrol may be the most effective compound for maintaining optimal health and promoting longevity1. Resveratrol is a phytoalexin, a polyphenolic compound which is produced by Vitis vinifera as a response to attack by molds. Because of the widespread use of pesticides in modern wine making, including the practice of copper sulfation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest and other factors. In fact, usually only one to three mg of resveratrol is currently found per liter of red wine, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement. Research funded by the Life Extension Foundation showed that a combination of low-dose (20 mg) resveratrol plus grape seed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Other studies, however, indicate that higher doses may be needed to obtain all of Resveratrol’s positive benefits including promoting healthy insulin sensitivity, enhanced mitochondrial function, reduced expression of inflammatory factors, and protection against the effects of a high-fat diet.2-16 Pterostilbene, a stilbene compound from the same family as resveratrol, has been shown to work synergistically with resveratrol, to unlock one’s longevity genes … thus conferring even greater anti-aging benefits. In laboratory tests, pterostilbene has shown promise for supporting cardiovascular health, glucose levels that are already within normal range, anti-aging and cognitive function17-24. It helps improve mitochondrial function and supports healthy metabolic function by activating SIRT1 and mimicking calorie restriction25,26. It has also shown potential to ease inflammation and support antioxidant activity. 27,28 Fisetin, found in strawberries, has the power to “switch on” cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function29. Fisetin also supports aging neurons in the presence of oxidative stress 30-33. Most importantly, it works in synergy with resveratrol. Researchers have uncovered compelling evidence of Fisetin’s ability to stabilize Resveratrol by shielding it from metabolic breakdown34, thus extending its beneficial effects! *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.