Life Extension Super Bio-CurcuminCurcumin is impressing scientists around the world with its remarkable multiple health benefits. Curcumin is a polyphenol present in the spice turmeric and was first used by Indians over 3,000 years ago in traditional Ayurvedic medicine.

Modern science has found that curcumin has remarkable antioxidative, immunomodulatory, proapoptotic, hepatoprotective and antiangiogenic properties.(1-6) Curcumin is also found to increase detoxifying enzymes and promote healthy DNA function.(7-11) Studies have tied inflammation to overexpression of a protein molecule called nuclear factor-kappa B (NF-kappaB). NF-kappaB acts like a switch to turn on genes that produce the body’s inflammatory responses. Because NF-kappaB’s expression increases in aging adults, scientists have sought ways to modulate NF-kappaB and its effects in the body. Curcumin has been shown to exert powerful inhibitory effects on NF-kappaB activation within the body.(12-15) Curcumin inhibits overexpression of NF-kappaB. In addition, curcumin inhibits the metabolism of arachidonic acid, as well as activities of cyclooxygenase, lipoxygenase, and cytokines (interleukins and tumor necrosis factor).(16-19) Other clinical trials suggest roles for curcumin in helping maintain healthy bowel and joint functions.(20-28) Curcumin can also help maintain normal healthy platelet function,(29-32) and have immunomodulatory effects by inhibiting histamine release from mast cells.(33-35) Other studies show curcumin’s potential for supporting healthy brain function and offering neuroprotection.(36-45) Curcumin may effectively support pancreatic islet health.(46-51) Curcumin’s multifaceted effects include protecting against estrogen-mimicking chemicals,(52-56) protecting against damaging free radicals, and promoting normal cell cycle growth. The problem is that curcumin is poorly absorbed into the bloodstream. Super Bio-Curcumin® absorbs up to seven times better than conventional curcumin. So this patented formula represents the most cost-effective way to supplement with this critical nutrient. Studies show that one 400 mg capsule a day of this turmeric compound can provide curcumin blood levels equal to ingesting 2,500–2,800 mg of commercial curcumin supplements. And not only does this turmeric formulation provide far greater peak blood levels, but the curcumin remains in the bloodstream almost twice as long as conventional supplements. And this enhanced absorption delivery complex provides other beneficial turmeric compounds in addition to standardized curcumin. Each 400 mg capsule of Super Bio-Curcumin® is equivalent to 2,772 mg of a typical 95% curcumin extract. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. References 1. Anticancer Res. 2004 Mar-Apr;24(2B):563-9.
2. Chem Soc Rev. 2008 Nov;37(11):2558-74.
3. Antioxid Redox Signal. 2008 Mar;10(3):511-45.
4. Arch Pharm (Weinheim). 2010 Sep;343(9):489-99.
5. J Ethnopharmacol. 2010 Mar 24;128(2):549-53.
6. Arch Toxicol. 2010 May;84(5):389-96.
7. Asia Pac J Clin Nutr. 2008;17 Suppl 1:265-8.
8. Phytother Res. 2010 Jan 13;24(2):189-192.
9. Zhonghua Nei Ke Za Zhi. 2009 Sep;48(9):760-3.
10. Mol Nutr Food Res. 2010 Aug;54(8):1192-201.
11. Nutr Cancer. 2010;62(2):148-53.
12. J Alzheimer’s Dis. 2004 Aug;6(4):367-7.
13. Surgery. 2012 Jan 26. [Epub ahead of print]
14. Anticancer Drugs. 2012 Jan 23. [Epub ahead of print]
15. Biol Pharm Bull. 2011;34(7):974-9.
16. Chin Med. 2008 Sep 17;3:11.
17. Int Braz J Urol. 2009 Sep-Oct;35(5):599-606.
18. Curr Drug Targets. 2011 Mar 1;12(3):332-47.
19. Trends Pharmacol Sci. 2009 Feb;30(2):85-94.
20. Dig Dis Sci. 2005 Nov;50(11):2191-3.
21. Biochem Pharmacol. 2008 Feb 15;75(4):787-809.
22. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.
23. Inflamm Bowel Dis. 2011 Feb;17(2):503-15.
24. PLoS One. 2010 Dec 3;5(12):e15099.
25. Indian J Pharmacol. 2011 Sep;43(5):546-50.
26. Genes Nutr. 2011 May;6(2):171-9.
27. J Fam Pract. 2011 Mar;60(3):155-6.
28. Arthritis Res Ther. 2011 Feb 3;13(1):102.
29. J Endotoxin Res. 2007;13(1):15-23.
30. Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):223-7.
31. Mol Cancer Ther. 2006 May;5(5):1371-82.
32. Platelets. 2011;22(4):270-6.
33. Mol Nutr Food Res. 2008 Sep;52(9):1031-9.
34. Arch Med Res. 2011 Feb;42(2):79-87.
35. J Ethnopharmacol. 2011 Jul 14;136(3):414-21
36. Journal of Neuroscience. 2001;21(21):8370–8377.
37. Journal of Biological Chemistry. 2005;280(7):5892–5901.; discussion 606-7.
38. Cellular and Molecular Life Sciences. 2006;63(13):1538–1552.
39. Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S189-94.
40. J Neurochem. 2010 Mar;112(6):1415-30.
41. Biochem Biophys Res Commun. 2010 Feb 19;392(4):567-71.
42. PLoS One. 2010 Jan 8;5(1):e8643.
43. Curr Drug Targets. 2011 Mar 1;12(3):332-47.
44. Indian J Pharm Sci. 2010 Mar;72(2):149-54.
45. Neuroscience. 2010 Sep 1;169(3):1296-306.
46. Eur J Pharmacol. 2007 Dec 22;577(1-3):183-91.
47. Br J Pharmacol. 2008 Nov;155(5):702-13.
48. Free Radic Res. 2011 Jul;45(7):788-95.
49. Nutr Metab (Lond). 2011 Jun 10;8(1):35.
50. Mol Nutr Food Res. 2011 Nov;55(11):1655-65.
51. Diabetes. 2011 Nov;60(11):2928-38.
52. Zhonghua Yi Xue Za Zhi. 2003 Oct 25;83(20):1764-8.
53. Biochem Biophys Res Commun. 1997 Apr 28;233(3):692-6.
54. Endocrinology. 2012 Feb;153(2):554-63.
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56. Evid Based Complement Alternat Med. 2012;2012:486568. Epub 2011 Jun 6.

Label Information

Supplement Facts
Serving Size: 1 vegetarian capsule
Servings Per Container: 60
Amount Per Serving%DV
BCM-95® Bio-Curcumin® (Curcuma longa) 25:1 extract (root) [std. to 95% Total Curcuminoids Complex with Essential Oils of Turmeric Rhizome by HPLC (380 mg)]400 mg*
* Daily Value not established

Bio-Curcumin® and BCM-95® are registered trademarks of Dolcas-Biotech, LLC. U.S. Patent Nos. 7,883,728, 7,736,679 and 7,879,373.

  • Suggested Use:

    Take one capsule daily with food, or as recommended by a healthcare practitioner.

  • Contraindications: Do not take if you have gallbladder problems or gallstones. If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product. Do not exceed recommended dose. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
  • Other Ingredients: rice flour, vegetable cellulose (capsule), vegetable stearate, silica. Contains rice.
  • Contains No: milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.