Folate is a water-soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits and beans. Research has established that supplementation with folate before and during the first two months of pregnancy can support proper neurological development in the fetus. Additionally, folate plays a key role in the metabolism of homocysteine. Homocysteine is a sulfur containing amino acid that is created in the body from methionine, an essential amino acid derived solely from dietary intake. High plasma levels of homocysteine appear to injure the vasculature, impairing the functional abilities of endothelial and smooth muscle cells.

Metafolin® folate is a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health, as it participates as a cofactor in a reaction that involves the remethylation of homocysteine to methionine. Unlike synthetic folic acid, 5-MTHF can be used directly by the body, without the need for an additional conversion via the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR). In certain populations, the body’s ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences. Metafolin® contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier. Metafolin® does not appear to mask the anemia associated with a vitamin B12 deficiency and presents no risk of an accumulation of unmetabolized folic acid in the body. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Label Information

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 60
Amount Per Serving%DV
Folate1,000 mcg250%
(as L-methylfolate, Metafolin®)  

Tamper resistant package, do not use if outer seal is missing. Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.

  • Suggested Use:

    As a dietary supplement, adults take 1 tablet daily, or as directed by your healthcare professional.

  • Storage: For optimal storage conditions, store in a cool, dry place. (59°-77°F/15°-25°C) (35-65% relative humidity). Store away from direct light.
  • Contraindications: Doses of 5 mg or higher per day can cause abdominal cramps, diarrhea, and rash.
  • Other Ingredients: cellulose, dicalcium phosphate, croscarmellose sodium, vegetable stearate and silica.
  • Contains No: yeast, gluten, soy protein, milk/dairy, corn, sugar, starch, artificial coloring, preservatives or flavoring.