ActiFolate is an exclusive, proprietary blend of three key forms of folate: folic acid, 5-formyl tetrahydrofolate, and L-5-methyl tetrahydrofolate (L-5-MTHF). This combination of folates uniquely supports healthy methylation, homocysteine levels, pregnancy, mental function, and other critical functions of folate.
Providing three forms of folate may better ensure optimal folate nutrition - even in those with genetic variations in folate metabolism (up to 40% of the population) who may not receive the vital benefits expected from dietary or supplemental folic acid.
ActiFolate is one of the supplements included in the Simplified Methylation Protocol for chronic fatigue syndrome (ME/CFS) and fibromyalgia that was developed by Drs. Neil Nathan, MD; Rich Van Konynenburg, PhD; Amy Yasko, PhD; and Jacob Teitelbaum, MD.
This group of supplements (FolaPro, ActiFolate, Perque Activated B-12 Guard, and Neurological Health Formula) has been selected and formulated to provide nutrients that the body needs to support normal methylation - a process that is critical for a host of the body's most important chemical reactions, from creation of glutathione (the body's 'master' antioxidant and detoxifier) to energy generation, DNA repair, and serotonin production.
Doses used in the Simplified Methylation Protocol trial* are as follows:
Actifolate: 1/4 tablet (200mcg) daily [60 tablets in bottle]
Folapro: 1/4 tablet daily [60 tablets in bottle]
General Vitamin Neurological Health Formula: Start with 1/4 tablet and work up, very slowly, to 2 tablets daily [180 tablets in bottle]
Activated B-12 Guard: 1 sublingual lozenge daily [100 tablets in bottle]
Note: As Dr. Nathan's trial report suggests, another supplement considered beneficial but not central to the protocol is phosphatidyl serine.