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ProHealth > Store Home > Antioxidants > Super R-Lipoic Acid

Super R-Lipoic Acid by Life Extension - 60 capsules

#N0583 - Antioxidant Supplement
$36.75 $49.00 SRP
You Save: $12.25 (25% Off)
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Bio-Enhanced® Active Form of Lipoic Acid

  • Supports healthy inflammatory response*
  • Supports healthy mitochondrial function*
  • Provides potent benefits for preserving youthful cellular energy levels*
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Unlike other forms of lipoic acid, Super R-Lipoic Acid is more stable in the body. The increased stability of this enhanced formulation is the reason for its greater absorption and bioavailability compared with R-lipoic acid.

Lipoic acid helps protect against oxidative stress generated by high glucose levels. Alpha-lipoic acid consists of two different forms (isomers) that have vastly different properties. The "R" form is the biologically active component (native to the body) that is responsible for lipoic acid's phenomenal antioxidant effect. The "S" form is produced from chemical manufacture and is not very biologically active. Typical alpha-lipoic acid supplements consist of the "R" and "S" form in a 50/50 ratio. That means a 100 mg alpha-lipoic acid supplement is providing 50 mg of the biologically active "R" form.

The human body normally produces and uses the "R" form of lipoic acid. This active form, R-lipoic acid, significantly supports healthy inflammatory response, is a potent free-radical scavenger and has been shown to be more potent than the combined "R" and "S" forms that comprise most alpha-lipoic acid supplements.(1-12)

Life Extension's Super R-Lipoic Acid has demonstrated superior bioavailability, stability, and potency for a variety of health benefits. This breakthrough converts the biologically active "R" form of lipoic acid to sodium-R-lipoic acid, which, in a recent human study achieved 10–30 times higher peak blood levels than pure R-lipoic acid.(13) Not only does this newer lipoic acid formulation reach higher peak blood levels,106 it also achieves them sooner, ensuring rapid uptake from the plasma into the tissues.105 A recent study showed that oral ingestion of Super R-Lipoic Acid reached peak plasma concentrations within just 10–20 minutes of supplementation.(14)


  1. Metabolism. 2008 Oct;57(10):1465-72.
  2. Brain Res. 2000 Feb 14;855(2):292-7.
  3. Ann N Y Acad Sci. 2002 Apr;959:491-507.
  4. J Neuroimmunol. 2011 Apr;233(1-2):90-6.
  5. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R587-97
  6. Pharmacol Res. 2011 Jan;63(1):23-9.
  7. Ann N Y Acad Sci. 2010 Aug;1203:151-9.
  8. Wien Klin Wochenschr. 2006 Mar;118(3-4):100-7.
  9. Free Radic Res. 2004 Oct;38(10):1083-92.
  10. Nutrition. 2001 Oct;17(10):888-95.
  11. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1463-70.
  12. Arch Pharm (Weinheim). 2010 Mar;343(3):133-42.
  13. Carlson DA, et al. Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. Taylor & Francis Publishers; 2008:235-70.
  14. Altern Med Rev. 2007 Dec;12(4):343-51.
  15. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.


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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.