Found in the Indian spice turmeric, curcumin is a polyphenol gift of nature that has been a staple of Ayurvedic medicine for thousands of years and has recently spurred hundreds of studies focused on understanding the key to its secrets. Much of the early curcumin research done in test tubes and animals has been positive, pointing to natural benefits and overall health. Universities and medical centers are looking at Longvida™ for a variety of areas that curcumin has shown beneficial effects. But when testing moved to human clinical trials, the results were much less dramatic - the main reason being that most curcumin supplements are not absorbed well by the body.
Now, after years of research and study, an elite group of neuroscientists at the University of California Los Angeles has developed Longvida™ Curcumin. This proprietary Curcumin formula has been shown to speed its way to plasma and reach its target at concentrations at least 65 times higher than generic curcumin.
How is Nutrivene Longvida™ different from generic curcumin?
Longvida™ addresses the key problem of proper absorption: the reason 'generic' curcumin shows great things in the test tube and in animals, but only insignificant positive trends in clinical trials. Patent-pending SLCP™ Technology ensures a safe, natural composition that promotes absorption into the bloodstream and various organs. And because it is about how much curcumin is absorbed, not what is consumed, large amounts of curcumin are no longer needed, thus reducing the chance for gastrointestinal irritation.
Data in clinical and preclinical trials at laboratories and medical centers strongly support Longvida's safety and potential effectiveness in supporting general and specific health issues, including cognition.*
What research is behind it?
Human and in vivo data on Longvida™ includes the following results:
- Curcumin from Longvida™ penetrates the bloodstream and the brain, and is one of the first to reach target concentrations in the body.*
- Longvida™ may significantly support cognition, memory, and general health.*
- Longvida™ reaches plasma at concentrations at least 65 times higher than generic curcumin.* (5,13,17)
What health conditions can Longvida™ be used for?
Curcumin has been studied for various health applications, including the promotion of longevity and cognitive health. As of June 2009, more than 2800 publications on curcumin were available through the NIH medical database and in ongoing human trials. Many have reported that Longvida™ may help promote joint health and flexibility, and help to modulate inflammatory responses already within the normal range. Curcumin is also a potent antioxidant and is used in skin products as an anti-microbial. Universities and medical centers are looking at Longvida™ for a variety of issues where curcumin has shown beneficial effects.
Is it safe?
The curcumin found in Longvida™ is a 100% natural, generally recognized as safe (GRAS) food additive, and has been used in traditional medicine and food for thousands of years. In clinical studies, curcumin showed a positive safety profile at doses of 8-12 grams (8,000-12,000 milligrams) per day.(7,22) Longvida™ is reported to have an excellent safety profile, and showed no acute high-dose toxicity at the highest dose tested, a dose equivalent to 1000 times the recommended dose.
*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Aggarwal BB, Bhatt ID, Ichikawa H, Ahn KS, Sethi G, Sandur SK, et al. Turmeric: the genus Curcuma. Taylor and Francis Group; 2006. p. 297-368.
2. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Mol Pharmacol 2006;69:195-206.
3. Baum L. et al. Letter in Journal of Clinical Psychopharmacology Volume 28, Number 1, February 2008 pp110-112.
4. Began G, Sudharshan E, Appu Rao AG. Lipids 1998;33:1223-8.
5. Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208.
6. Bundy R, Walker AF, Middleton RW, Booth J. J Altern Complement Med 2004;10:1015-8.
7. Cheng AL, Hsu CH, Lin JK, et al. Anticancer Res. 2001;21:2895-2900.
8. Cho JW, Lee KS, Kim CW. Int J Mol Med 2007;19:469-74.
9. Conteas CN, Panossian AM, Tran TT, Singh HM. Dig Dis Sci. 2008 Dec 3.
10. Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, et al. Clin Gastroenterol Hepatol 2006;4:1035-8
11. Deodhar SD, Sethi R, Srimal RC. Indian J Med Res 1980;71:632-4.
12. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R. Clin Cancer Res. 2008 Jul 15;14(14):4491-9.
13. Frautschy, SF. 38th Annual Meeting of the Society of Neuroscience , Washington DC, November 15, 2008.
14. Ganguli M, Chandra V, Kamboh MI, Johnston JM, Dodge HH, Thelma BK, Juyal RC, Pandav R, Belle SH, DeKosky ST. Arch Neurol. 2000 Jun;57(6):824-30.
15. Garcea G, Berry DP, Jones DJ, Singh R, Dennison AR, Farmer PB, et al. Cancer Epidemiol Biomarkers Prev 2005;14:120-5.
16. Goel A, Kunnumakkara AB, Aggarwal BB. Biochem Pharmacol. 2008 Feb 15;75(4):787-809. Epub 2007 Aug 19.
17. Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. J Ag Food Chem Submitted 2009.
18. Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, et al. Clin Gastroenterol Hepatol 2006;4:1502-6
19. Holt PR, Katz S, Kirshoff R. Dig Dis Sci 2005;50:2191-3.
20. Lal B, Kapoor AK, Agrawal PK, Asthana OP, Srimal RC. Phytother Res. 2000;14:443-447.
21. Lal B, Kapoor AK, Asthana OP, Agrawal PK, Prasad R, Kumar P, et al. Phytother Res 1999;13:318-22.
22. Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, et al. BMC Complement Altern Med 2006;6:10.
23. Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH. Am J Epidemiol 2006;164:898-906.
24. Ono et al. J Neurosci Res. 2004 Mar 15;75(6):742-50.
25. Satoskar RR, Shah SJ, Shenoy SG. Int J Clin Pharmacol Ther Toxicol 1986;24:651-4.
26. Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, et al. Clin Cancer Res 2001;7:1894-900.
27. Shishodia S, Singh T, Chaturvedi MM. Adv Exp Med Biol 2007;595:127-48.
28. Shoskes D, Lapierre C, Cruz-Correa M, Muruve N, Rosario R, Fromkin B, et al. Transplantation 2005;80:1556-9
29. Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J. Int J Mol Med 2003;12:17-24.
30. Soni KB, Kuttan R. Indian J Physiol Pharmacol 1992;36:273-5.
31. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, et al. J Biol Chem 2005;280:5892-901.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.