Liver Nutrients, by Seeking Health, is a specialty formula that provides a balanced combination of nutrients that enhance and protect hepatic function by supporting liver detoxification processes and enzymatic pathways, and providing antioxidant support.*
Why choose Liver Nutrients by Seeking Health?
The liver is the body’s central detoxification organ, responsible for deactivating environmental toxins as well as those generated endogenously. If liver detoxification is compromised, either by poor nutritional status, excessive toxin exposure, or illness, toxins may accumulate with considerable negative health consequences. The liver is equipped with several detoxification pathways, including excretion of toxins via bile, filtration of toxins from blood, and a two-phase enzymatic neutralization process, known as Phase I and Phase II.
The majority of toxins (including xenobiotics, steroid hormones, and metabolic by-products) entering Phase I are converted by a family of enzymes, referred to as cytochrome P450 mixed function oxidases, into intermediates that are often more toxic than their precursor molecules. The intermediate metabolites are then neutralized during Phase II conjugation reactions via glutathione and amino acid conjugation, sulfation, methylation, acetylation, and glucuronidation. These Phase II reactions create water-soluble intermediates that are then excreted in urine and bile.*
Free radicals are generated as a result of Phase I reactions. Thus, it is critical to support a proper balance of Phase I and Phase II activities to support healthy cell and cellular processes.* There are numerous hepatoprotective nutrients that support Phase I and Phase II activities and protect against excessive free radical generation. Phase I and II reactions are critically dependent upon the availability of numerous nutrients. Liver Nutrients provides several of these key nutrients as well as milk thistle extract which has unique hepatoprotective and regenerative properties.*
With the combination of 5 key ingredients, Liver Nutrients supports liver detoxification while providing antioxidant support.
1. Milk Thistle (Silybum marianum)
Milk thistle extract is rich in the flavonolignins silybin, silydianin, and silychristin, collectively referred to as silymarin. Unique to milk thistle, silymarin is well documented in scientific literature as a powerful hepatoprotective flavonoid complex. Silymarin both enhances and protects healthy liver function through three principal mechanisms. Acting at the cell membrane, silymarin protects hepatic cells by blocking the transportation of hepatotoxins into the liver. Silymarin also acts as an antioxidant, protecting against lipid peroxidation. Silymarin further contributes to the liver’s antioxidant defenses by enhancing glutathione levels, a leading hepatic antioxidant. In addition to its protective functions, silymarin has regenerative properties in the liver. By stimulating protein synthesis, silymarin promotes the regeneration of damaged cells.*
N-Acetyl-L-Cysteine (NAC) offers numerous hepatoprotective benefits that are primarily the result of its ability to increase endogenous glutathione levels and reduce oxidative stress. When metabolized, NAC generates L-cysteine, which is a precursor of glutathione. Glutathione deactivates many pro-oxidants, including hydroxyl radicals and superoxide radicals, and is required for the synthesis of glutathione peroxidase, another important liver antioxidant. NAC has been shown to increase endogenous synthesis of glutathione when demand for this potent antioxidant is high. NAC is itself a powerful antioxidant, capable of neutralizing hydrogen peroxide, hypochlorous acid, and hydroxyl radicals. Experimental studies indicate that NAC may protect the integrity of mitochondrial superoxide dismutase and glutathione peroxidase, two crucial hepatic antioxidants.*
3. Alpha-Lipoic Acid
Alpha-lipoic acid is a powerful antioxidant that is both water and fat soluble, and thereby able to offer an unusually wide range of antioxidant protection. Alpha-lipoic acid not only protects the liver by deactivating free radicals, but it also helps build up the body’s antioxidant defenses by recycling other antioxidants, including glutathione and vitamins C and E. Alpha-lipoic acid has been shown beneficial in supporting healthy detoxification.*
Taurine is involved in a variety of detoxification processes, including bile acid conjugation, reduction of oxidative stress, and select Phase II detoxification pathways. In order to clear toxins, cholesterol, and excess fat-soluble vitamins from the body, bile acids form bile salt conjugates by binding with either taurine or glycine. As an antioxidant, taurine helps reduce oxidative stress by neutralizing hypochlorous acid. Finally, taurine is involved in the Phase II amino acid conjugation detoxification pathway in which specific amino acids bind to and deactivate toxins. Activity of another Phase II detoxification pathway, sulfation, may also be enhanced by taurine. Taurine can be synthesized endogenously in the liver using L-cysteine and L-methionine.*
5. Trimethylglycine (betaine)
Trimethylglycine has been shown to help protect the liver against damage following carbon tetrachloride exposure in animal studies. Betaine has also been shown in animal studies to raise hepatic levels of S-adenosylmethionine (SAM) of both control animals as well as those fed ethanol. Studies in both animals and humans have shown SAM to be protective against the development of fatty liver that can occur with ethanol ingestion.*
What you need to know:
Maintenance and protection of liver function is known to be optimized by adequate intake of many additional nutritional factors, including the antioxidant vitamins C and E, beta-carotene, B vitamins, and selenium. It is thus recommended that Liver Nutrients be taken in conjunction with Optimal Multivitamin by Seeking Health comprehensive nutritional support of liver health.*
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results may vary.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.