ProMito PQQ™ is a unique blend that combines PQQ (a nutrient that stimulates mitochondrial growth and ATP production) and Alpha GPC (which delivers the essential nutrient choline to the brain) to power-up improved mental processing.
In vitro and clinical research suggests these two novel ingredients support healthy levels of nerve growth factor and receptor activity to promote neurological health, and boost memory retention and mental acuity.*
Pyrrolloquinoline (PQQ) is an enzyme cofactor functionally related to the B vitamin family. First recognized as an enzyme cofactor in bacteria, additional findings indicate it may have been present throughout early biological development. Recent evidence indicates PQQ can support several signal transduction pathways that are important in maintaining mitochondrial homeostasis and oxidative function, as well as supporting healthy levels of nerve growth factor and receptor activity.*
In humans, PQQ has been scientifically studied for its neuroprotective properties.* In one double blind placebo controlled study in middle aged and elderly adults, supplementation with PQQ was found to support healthy cognitive function, including high end mental processing.*
Human studies also indicate that the pro-phospholipid Alpha GPC (alpha glycerlphosphorylcholine) may support normal memory and neurological functioning in adults.*
Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.J Biol Chem. 2010 Jan 1;285(1):142-52.
Nunome K, Miyazaki S, Nakano M, Iguchi-Ariga S, Ariga H. Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1.Biol Pharm Bull. 2008 Jul;31(7):1321-6.
Rucker R, Chowanadisai W, Nakano M. Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev. 2009 Sep;14(3):268-77.
Ohwada K, Takeda H, Yamazaki M, Isogai H, Nakano M, Shimomura M, Fukui K, Urano S Pyrrolquinoline Quinonen(PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats. J Clin Biochem Nutr; 2007, 42: 29- 34.
Zhang Y, Rosenberg PA. The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation.Eur J Neurosci. 2002 Sep;16(6):1015-24.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.