Perque Activated B-12 Guard is in lozenge form for maximum uptake and optimal delivery to the brain. Studies on Perque Activated B-12 Guard lozenge formulation show nearly the same B-12 uptake as from injection. Patients notice that they feel better more quickly.*
Vitamin B-12 in our food supply is estimated to be 78% less than in the 1960s. Diet alone is hard pressed to provide the necessary levels of this important nutrient. In addition, stress and reduced hydrochloric acid (HCl) and intrinsic factor production in the stomach impair absorption. The most commonly used forms of B-12 require activation in the body, making uptake quite low - rarely more than 50%.*
Perque delivers vitamin B-12 in its superior, activated hydroxocobalamin form. Hydroxocobalamin lasts longer and raises B-12 blood concentrations higher than other forms. Hydroxocobalamin requires no intrinsic factor and is taken up directly by mucous membranes regardless of digestive competence.* Hydroxocobalamin is easily converted to active but short-lived methylcobalamin and adenosylcobalamin as needed in the body. Hydroxocobalamin, the parent to other B-12 forms, provides better, long-lived B-12 action in the body.
Perque Activated B-12 Guard is one of the supplements included in the Simplified Methylation Protocol for chronic fatigue syndrome (ME/CFS) and fibromyalgia that was developed by Drs. Neil Nathan, MD; Rich Van Konynenburg, PhD; Amy Yasko, PhD; and Jacob Teitelbaum, MD.
This group of supplements (FolaPro, ActiFolate, Perque Activated B-12 Guard, and Neurological Health Formula) has been selected and formulated to provide nutrients that the body needs to support normal methylation - a process that is critical for a host of the body's most important chemical reactions, from creation of glutathione (the body's 'master' antioxidant and detoxifier) to energy generation, DNA repair, and serotonin production.
Doses used in the Simplified Methylation Protocol trial* are as follows:
Actifolate: 1/4 tablet (200mcg) daily [60 tablets in bottle]
Folapro: 1/4 tablet daily [60 tablets in bottle]
General Vitamin Neurological Health Formula: Start with 1/4 tablet and work up, very slowly, to 2 tablets daily [180 tablets in bottle]
Activated B-12 Guard: 1 sublingual lozenge daily [100 tablets in bottle]
Note: As Dr. Nathan's trial report suggests, another supplement considered beneficial but not central to the protocol is phosphatidyl serine.
Activated B-12 Guard for SAMe
Optimal absorption of vitamin B-12 is essential to keep SAMe (S-adenosyl methionine) in its beneficial form. SAMe is critical for the manufacture of brain chemicals and for detoxification.*
Promotes Heart Health
The correlation between homocysteine (an amino acid that at elevated levels in the body may indicate an increased risk of cardiovascular disease) and vitamin B-12 is significant. Nearly 57% of men with elevated homocysteine have low levels of B-12. Signs of deficiency may take as long as six or more years to manifest clinically. Meanwhile, as homocysteine levels climb, cardiovascular risk rises. B-12 Guard, taken with the synergistic nutrients B-6 and folic acid, delivers maximum action for keeping homocysteine levels low.*
Hectic lifestyles, stress, and increasing levels of toxins in the environment can lead to exhaustion. Individuals suffering from fatigue can benefit from B-12 supplementation. B-12 stimulates the body's utilization of proteins, fats, and carbohydrates, which in turn can increase energy. Research shows that 2-20 mg. (2,000 - 20,000 mcg) daily is required for optimal benefit. Each B-12 Guard lozenge delivers 2,000 mcg of B-12.*
More About Homocysteine and B-12
The importance of maintaining normal homocysteine levels cannot be overemphasized. Your heart health depends on it. Clearly, the scientific evidence indicates that nutrient deficiency is a factor in elevated homocysteine levels. However, in a recent study, researchers discovered that in many patients, even when serum levels of vitamins appear to be normal, homocysteine concentrations were still too high.*
Elevated homocysteine levels are implicated in much more than heart disease. In a study of women with both chronic fatigue syndrome and fibromyalgia, researchers discovered that all of the patients had high levels of homocysteine in their cerebrospinal fluid. They also noted a significant correlation between high homocysteine levels and fatigue. The study emphasized the importance of the relationship between B-12 and homocysteine, and showed that B-12 deficiency was a contributing factor. By decreasing levels of homocysteine in the central nervous system, B-12 can help prevent and treat fatigue.*
1. Glueck CJ, et al.: Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients. Am J Cardiol 1995 Jan 15; 75: 132-136.
2. Andres E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, Noblet-Dick M, Maloisel F, Schlienger JL, Blickle JF. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 2004 Aug 3;171(3):251-9.
3. Abalan F, Subra G. Picard M, Boueilh P. Incidence of vitamin B-12 and folic acid in patients admitted to a geriatric psychiatry unit. [Article in French] Encephale 1984; 10: 9-12.
4. Nilsson K, Gustafson L, Hultberg B: Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population. Dement Geriatr Cogn Disord 1999 November-December; 10(6): 467-482.
5. Regland B, Andersson M, Abrahamson L, Bagby J, Dyrehag LE, Gottfries CG: Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997; 26(4): 301-307.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat or prevent any disease.