ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Clinical Results Suggest Drug Could Rival COX-2 Inhibitors in Treating Osteoarthritis

  [ 92 votes ]   [ Discuss This Article ] • June 21, 2002

The results of the first phase III clinical trials for the new osteoarthritis drug licofelone, have shown comparable efficacy to conventional NSAIDs but with excellent gastrointestinal (GI) and general tolerability. These results are similar to those achieved in the original development of COX-2 inhibitors; however, the action of licofelone should also avoid the possible disadvantages of COX-2 inhibitors and may therefore offer additional benefits for the treatment of osteoarthritis (OA).

According to data presented at the 2002 European League Against Rheumatism (EULAR) congress in Stockholm, licofelone inhibits both 5-LOX and COX enzymes in the inflammatory pathway and appears in theory, and now in clinical trials, to offer benefits over selective COX-2 inhibitors in the treatment of osteoarthritis. The most recent data presented by Professor Jean-Yves Reginster, of the University of Liege, Belgium, show licofelone to be as effective as the traditional NSAID, naproxen and with excellent GI and general tolerability.

"The trials in which we were involved start to show that our expectations for the benefits of 5-LOX/ COX inhibitors in treating osteoarthritis are well founded. Licofelone appears to offer comparable efficacy to the highly effective treatment naproxen, but with excellent GI, renal, hepatic and general tolerability," Reginster said.

Current treatment options for the inflammation and pain of osteoarthritis include conventional NSAIDs (such as the naproxen used in this study) and selective COX-2 inhibitors. Conventional NSAIDs effectively inhibit the COX-1 and COX-2 pathway, but have a high risk of adverse GI events. Selective COX-2 inhibitors have remained the main focus of research due to their early success and major pharmaceutical backing. Currently available COX-2 inhibitors have also demonstrated a reduction in gastrointestinal effects compared with the traditional NSAIDs.

However, it is now becoming clear that some COX-2 inhibitors may also be associated with an increased risk of GI events, and it is now being suggested, through the development of licofelone, that the balanced inhibition of the 5-LOX and COX pathways may provide a new alternative with an optimal benefit/risk ratio.

Professor Stefan Laufer, University of Tuebingen, Germany who is the researcher credited with discovering licofelone commented, “An extensive, published, pre-clinical program has demonstrated the anti-inflammatory and analgesic efficacy of licofelone. These results are now being confirmed in phase III studies, the first of which have been presented today. Licofelone has passed the stage of being interesting research and has now become a real potential alternative in optimizing the future treatment of osteoarthritis. We look forward to seeing the next available data which we hope will further support these findings and allow the companies involved to make a license submission to support the availability of the treatment for clinicians use as soon as possible."

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Energy NADH™ 12.5mg FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map