NAD+ Triple Boost™ - 500 mg NIAGEN®, 30 capsules

SKU: PH642

Sale price

Regular price $89.95
( / )

Select Size

  • Have questions about this product?
    Ask one of our experts.
  • click here

Free Nutritional Advisor

Free Nutritional Advisor

NAD+ Triple Boost is our most advanced formula available to protect against the cellular damage at the root of aging.

This breakthrough patent-pending formula is designed for those looking to boost their NAD+ levels beyond what taking NMN or NR can do on their own. This first-of-its-kind formula enhances the longevity effect by actively increasing NAD+ levels and by protecting NAD+ from being prematurely broken down in the body.

The supplement combines three research-backed nutrients that work synergistically to increase and maintain NAD+ levels:

  • Niagen® form of , a clinically proven member of the vitamin B3 family to boost NAD+.
  • Apigenin an antioxidant that protects against NAD+ decline by modulating the activity of the NAD-consuming enzyme CD38.
  • Tryptophan, an essential amino acid that promotes NAD+ production via the De Novo Synthesis Pathway, a process involved in NAD+ creation when cells need additional support.
NAD+ Triple Boost can support NAD+ levels far more than a single NAD+ booster taken on its own. Unlike other NAD+ supplements on the market that contain just one NAD-increasing nutrient, ProHealth's NAD+ Triple Boost helps reduce the symptoms of age-related health decline by addressing each of the main causes of declining NAD+ levels in a single convenient daily capsule.

NAD+ Triple Boost

  • Activates all 3 metabolic pathways responsible for NAD+ production and recycling
  • Protects against accelerated NAD+ loss with apigenin
  • Enhances longevity by actively increasing NAD+ levels with Niagen® NR
  • Promotes heart function by supporting healthy blood flow and endothelial function
  • Protects the brain from age-related decline to maintain memory and neuroplasticity
  • Supports healthy methylation patterns for youthful epigenetic gene expression+

View Certificate of Analysis

Research-Supported Benefits:

Promotes Longevity. NAD+ Triple Boost promotes longevity by increasing NAD+ levels in three critical, but different ways. NR is an NAD+ precursor, which directly and significantly increases NAD+ levels within the body. (1) Apigenin further increases NAD+ by inhibiting the activation of the CD38 enzyme, which is an NAD+ consuming enzyme that contributes to accelerated decline of NAD+ levels. (2) Tryptophan plays an additional role in the creation of NAD+ through the De Novo Synthesis Pathway, a process which uses available building blocks to increase NAD+ levels in the body in times of need. (3)

Improves Cellular Health. By increasing NAD+ levels, NAD+ Triple Boost aids in facilitating DNA repair. (4) Research shows that DNA damage is associated with increased risk of age-related health decline and the development of a variety of chronic health concerns, highlighting the importance of the DNA repair process. By increasing NAD+ levels, NAD+ Triple Boost provides fuel for sirtuins (longevity genes), which are critical proteins responsible for protecting the health and longevity of each of our cells.

Enhances Heart Health. Maintaining healthy NAD+ levels is critically important for protecting the heart from age-related health decline. Research shows that NR enhances heart health by reducing stiffness of the aorta, which is the largest artery in the human body. (5) The aorta carries oxygenated blood from the heart to the rest of the body, and aortic stiffness is associated with increased risk of blood pressure dysregulation and a decline in overall cardiac function. (6)

Enhances Brain Health. Low levels of ergothioneine are correlated with neurodegeneration and cognitive impairment. (7) Animal studies have found that administration of ergothioneine improves markers of memory and mood. (8)

Protects Against Cognitive Decline. Research suggests age-related NAD+ decline is a contributing factor to many of the hallmark signs of brain aging. Increasing NAD+ levels with NAD+ precursors such as Nicotinamide Riboside shows promise in supporting healthy brain aging and enhancing cognitive function. (7)

Supports Healthy Methylation. The methylation process is a fundamental biochemical process within the body that plays roles in neurotransmitter production, detoxification, liver function, and longevity. While research is still ongoing, preliminary evidence suggests supplementing with NAD+ precursors such as NR may deplete "methyl donor" nutrients in the body, hindering the methylation process from functioning optimally. Some B-vitamins such as methylcobalamin (the biologically active form of vitamin B-12 found in NAD+ Triple Boost), support healthy methylation by aiding in the production of SAMe, a key methyl donor that participates in methylation reactions throughout the body. (8)


1. Fang EF, Lautrup S, Hou Y, et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med. 2017;23(10):899-916. doi:10.1016/j.molmed.2017.08.001

2. Sharma A, Chabloz S, Lapides RA, Roider E, Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023;15(2):445. Published 2023 Jan 14. doi:10.3390/nu15020445

3. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141. doi:10.1038/s41580-020-00313-x

4. Wilk A, Hayat F, Cunningham R, et al. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Sci Rep. 2020;10(1):651. Published 2020 Jan 20. doi:10.1038/s41598-020-57506-9

5. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. Published 2018 Mar 29. doi:10.1038/s41467-018-03421-7

6. Bonarjee VVS. Arterial Stiffness: A Prognostic Marker in Coronary Heart Disease. Available Methods and Clinical Application. Front Cardiovasc Med. 2018;5:64. Published 2018 Jun 11. doi:10.3389/fcvm.2018.00064

7. Lee HJ, Yang SJ. Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice. Int J Mol Sci. 2019;20(17):4196. Published 2019 Aug 27. doi:10.3390/ijms20174196

8. Vaccaro JA, Naser SA. The Role of Methyl Donors of the Methionine Cycle in Gastrointestinal Infection and Inflammation. Healthcare (Basel). 2021;10(1):61. Published 2021 Dec 29. doi:10.3390/healthcare10010061

  • NAD+ levels decline with age, with an estimated 50% decline in NAD+ levels by age 50
  • Longevity researchers believe NAD+ decline is one of the main causes of cellular aging
  • Research shows that increasing NAD+ levels in aged animals extends lifespan
  • NAD Triple Boost addresses three of the key factors associated with NAD+ decline, helping to restore youthful NAD+ levels
  • The Niagen® NR found in Triple Boost is clinically proven to significantly increase NAD+ levels
  • While NR directly increases NAD+ levels, the apigenin contained in NAD+ Triple Boost protects against NAD+ from declining in the first place by decreasing the activity of the NAD-consuming enzyme CD38.
  • The tryptophan contained in NAD+ Triple Boost promotes NAD+ production by serving as a key component of the De Novo Synthesis Pathway, a process that is involved in NAD+ creation when cells need additional support.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 30
Amount Per Serving %DV
Vitamin B2 (as Riboflavin) 4 mg 310%
Vitamin B3 (as Nicotinic Acid) 20 mg 120%
Vitamin B6 (as Pyridoxal-5-Phosphate) 5 mg
Vitamin B12 (as Methylcobalamin) 5 mcg
Nicotinamide Riboside Chloride (Niagen®) 500 mg

Tryptophan 60 mg

Apigenin (Apium graveolens Extract 98%) 20 mg

BioPerine® (Black Pepper Extract) 10 mg

† Daily Value not established

REV. 11.23

Niagen® is a trademark of ChromaDex, Inc.

BioPerine® is a registered trademark of Sabinsa, Co.

  • OTHER INGREDIENTS: Vegetable capsule, rice flour.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 capsule per day, or as directed by your healthcare professional.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper evident seal is broken or missing.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. KEEP OUT OF REACH OF CHILDREN.
  • Unique Formulation. ProHealth’s NAD+ Triple Boost was specifically formulated to reduce symptoms of age-related health decline by addressing each of the main causes of declining NAD+ levels.
  • Effective form and dosing: Compared to other brands on the market containing only one nutrient geared toward increasing NAD+single, ProHealth’s Triple Boost Pro contains three powerful nutrients that work synergistically to restore NAD+ to youthful levels.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

which supplements are right for you?

Our Longevity Health Pros are just a text away with supplement & dietary answers, guidance & support.

Benefits +
How it Works +
How Ours is Better +
Label Information +
Benefits +
How it Works +
How Ours is Better +
Label Information +

Customer Reviews

Based on 6 reviews
Bruce B.
Sustained Energy Without Caffeine!

One of the few supplements I take that has an effect that makes taking caffeine practically unnecessary. The sustained energy it provides does not cause any jitters unlike caffeine can either.

Sheena M.

NAD+ Triple Boost™ - 500 mg NIAGEN®, 30 capsules

loved it!

simple straoght clean

Claudia H.
I like it

Would recommend.

Jina B.
One and done

Amazing to get so many awesome ingredients packed into one supplement! We know how good {N}{M}{N} is for us, so to have a product that gives you benefits beyond that is great. And having tryptophan is a huge added bonus for me! This is an excellent preventative product and I expect to see results in the long term from consistent use.

Rejuvenated and refreshed.

I have more energy, focus, and mental clarity than ever before. The 500mg of NIAGEN® in each capsule is what my body needs to feel rejuvenated and refreshed. I highly recommend NAD+ Triple Boost™ to anyone looking to optimize their overall health and wellness!

Frequently asked questions

While NR and tryptophan can be taken with or without food, some flavonoids (like apigenin), are better absorbed in the presence of healthy fats. Therefore, Triple Boost Pro is best taken with a healthy fat such as olive oil, avocados, or grass-fed yogurt.
NAD+ Triple Boost uses a synergistic blend of ingredients that have been shown in trials to each promote youthful NAD+ levels through SEPARATE mechanisms, effectively using three different methods to promote NAD+ production. Typical NAD+ boosters utilize only one pathway, limiting the amount of NAD+ you can produce and use. With NAD+ Triple Boost, you will have a wraparound approach to protect against age-related NAD+ loss and the functional decline seen in aging.