ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

New drug blocks opioid/morphine's respiratory suppression but not pain relief potency – animal trials

  [ 11 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 6, 2010


A new drug called repinotan blocks the respiratory depressant effects of morphine-like opioid drugs - without altering their potent pain-relieving effects, according to a study published Oct 1 in Anesthesia & Analgesia.

If the promising results of animal studies are borne out by future research, then repinotan could become an important part of safe, effective pain control after surgery.

The researchers, led by Dr. Ulf Guenther, MD, at the University Hospital of Bonn, Germany, performed a series of experiments to see how repinotan influenced the effects of morphine.

Although morphine and related drugs (opioids) are highly effective in treating pain after surgery, they share a common characteristic: They decrease the drive to breathe. This is a potentially serious side effect that can limit the use of opioid drugs for pain control.

In the study, rats were given a morphine dose high enough to slow the breathing rate. When the animals were subsequently treated with repinotan:

• Their respiratory rate rapidly returned toward normal.

• At the same time, repinotan did not alter the pain-blocking effects of morphine.

This is especially important because, although other drugs are available to reverse the respiratory depressant effects of opioids, they also reverse the pain-relieving effects.

There were no serious cardiovascular side effects with repinotan, although it did cause a drop in blood pressure.

"For years, investigators have tried to develop an opioid that produced the profound analgesia of morphine, but without the effects on breathing rate," explains Anesthesia & Analgesia Editor-in-Chief Dr. Steven L. Shafer of Columbia University.
 
More recently, specific types of drugs have been developed that selectively reverse morphine-induced depression of breathing. Repinotan is the first drug of this type that has proven suitable for studies in humans.

"This is an incredibly exciting development in opioid pharmacology," Dr. Shafer adds.

"A drug that blocks the ability of opioids to suppress breathing, while not interfering with the pain relief, would be a huge advance in pain management and patient safety,” he says. “Unless the drug had other toxicities, such a drug would immediately become the standard of care for post-operative patients receiving opioids."

Source: International Anesthesia Research Society news release, Oct 5, 2010




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Breaking Through the Mental Fog Breaking Through the Mental Fog
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
"It's Not Easy Being Green" - But It Is Healthy

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map