Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The New Dual Activation Pain Relief Cream

SURVEY RESULTS: Medical Marijuana

Recipe: Mega-Golden Milk

Vitamin D supplementation shows promise for Hashimoto's thyroiditis

Sweep Away Senile Cells

A Paleolithic-type diet may help reduce future risk of diabetes and cardiovascular disease

Large whey protein breakfast may help manage type 2 diabetes

Decreased levels of vitamin D associated with reduced methylation in African American teens

Selenium — What Is it and Where Do I Get It?

Meta-analysis adds evidence to antidepressant effect for omega-3

 
Print Page
Email Article

New drug blocks opioid/morphine's respiratory suppression but not pain relief potency – animal trials

  [ 11 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 6, 2010


A new drug called repinotan blocks the respiratory depressant effects of morphine-like opioid drugs - without altering their potent pain-relieving effects, according to a study published Oct 1 in Anesthesia & Analgesia.

If the promising results of animal studies are borne out by future research, then repinotan could become an important part of safe, effective pain control after surgery.

The researchers, led by Dr. Ulf Guenther, MD, at the University Hospital of Bonn, Germany, performed a series of experiments to see how repinotan influenced the effects of morphine.

Although morphine and related drugs (opioids) are highly effective in treating pain after surgery, they share a common characteristic: They decrease the drive to breathe. This is a potentially serious side effect that can limit the use of opioid drugs for pain control.

In the study, rats were given a morphine dose high enough to slow the breathing rate. When the animals were subsequently treated with repinotan:

• Their respiratory rate rapidly returned toward normal.

• At the same time, repinotan did not alter the pain-blocking effects of morphine.

This is especially important because, although other drugs are available to reverse the respiratory depressant effects of opioids, they also reverse the pain-relieving effects.

There were no serious cardiovascular side effects with repinotan, although it did cause a drop in blood pressure.

"For years, investigators have tried to develop an opioid that produced the profound analgesia of morphine, but without the effects on breathing rate," explains Anesthesia & Analgesia Editor-in-Chief Dr. Steven L. Shafer of Columbia University.
 
More recently, specific types of drugs have been developed that selectively reverse morphine-induced depression of breathing. Repinotan is the first drug of this type that has proven suitable for studies in humans.

"This is an incredibly exciting development in opioid pharmacology," Dr. Shafer adds.

"A drug that blocks the ability of opioids to suppress breathing, while not interfering with the pain relief, would be a huge advance in pain management and patient safety,” he says. “Unless the drug had other toxicities, such a drug would immediately become the standard of care for post-operative patients receiving opioids."

Source: International Anesthesia Research Society news release, Oct 5, 2010




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Aching for Pain Relief?

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map