ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Exercises to Help Prevent Urinary Incontinence

Higher red blood cell omega 3 levels in women linked to lower risk of mortality over 14.9 year media...

 
Print Page
Email Article

A mouse virus, XMRV, closely related to porcine endogenous retroviruses in the human population – A new risk for xenotransplanation? – Source: Xenotransplanation, Feb 22, 2011

  [ 5 votes ]   [ Discuss This Article ]
By J Denner • www.ProHealth.com • April 6, 2011


[Note: Xenotransplantation is the transplantation of living cells, tissues or organs from one species to another – most frequently in current medical practice, from pigs to humans. A transplant of human to human would be an allotransplant.]

There is a need to carefully consider the potential infectious risks associated with xenotransplantation.

Whereas known viruses can easily be eliminated from donor pigs by designated pathogen free breeding of the animals, this is not possible for porcine endogenous retroviruses (PERVs) integrated into the genome of all pigs and unknown viruses.

PERVs infect human cells in vitro [in laboratory cultures] and may theoretically - like many retroviruses - induce immunodeficiencies and/or tumors.

Recently a xenotropic murine leukemia virus related virus (XMRV), a gammaretrovirus that is closely related to murine leukemia viruses as well as to PERV, has been detected in human patients with prostate carcinoma, chronic fatigue syndrome (CFS) and also in a small percentage of clinically healthy individuals.

Whereas several studies showed a broad distribution of XMRV in the USA, similar studies in Europe failed to detect this virus in the human population (for review see 1). [Note: This does not appear to consider positive European studies.] These results clearly indicate that XMRV is not causally associated with prostate carcinoma and CFS.

Either the virus is common in the USA (may be there are specific populations of rodents releasing this virus) and not in Europe, or it is a laboratory contamination.

If XMRV is indeed circulating in the human population, it has important implications for xenotransplantation.

A test should be developed to discriminate between PERV and XMRV and the potential for recombination between the two viruses should be investigated.

Recombination between the human tropic PERV-A and the ecotropic PERV-C has been described and recombinant PERV-A/C was characterized by increased replication titers.

Whether XMRV and PERV recombine remains unclear, however co-packaging and pseudotyping between PERV and murine retroviruses have been described.

This raises new questions:

• Should the xenotransplant recipient be pre-screened for XMRV to avoid recombination?

• What measures can be taken when XMRV infection is detected in such a screen?

However, before dealing with these specific details, it is necessary to address the important broad questions concerning the distribution of XMRV and its impact on human health.

1. Reference: Denner J. Detection of a gammaretrovirus, XMRV, in the human population: Open questions and implications for xenotransplantation. Retrovirology 2010; 7: 16.

Source: Xenotransplanation, Feb 22, 2011;18(1). From Berlin Symposium on Xenotransplantation. Denner J, Robert Koch Institute, Berlin, Germany.




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map