ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Option For Chronic Fatigue Syndrome

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

Stop Bacteria With Nature's Antibiotics

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

New Test Shows Promise in Identifying New Drugs to Treat Lyme Disease

Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

Strengthen Cell Function with Energy-Boosting Niagen

Vitamin D deficiency increases poor brain function after cardiac arrest by sevenfold

Dietary Flavanols Reverse Age-Related Memory Decline

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

 
Print Page
Email Article

Greater arthritic knee inflammation & damage associated with lower serum omega-3

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 9, 2012


Article:
Association of plasma omega-6 and omega-3 polyunsaturated fatty acids with synovitis in the knee: The MOST study
- Source: Osteoarthritis and Cartilage, Feb 4, 2012

By Kristin R Baker, et al.

[Note: Synovium is a thin layer of cells lining the joints and joint-stabilizing tendons, which when healthy produces joint lubricating synovial fluid. The ideal omega-3 to omega-6 ratio is thought to be 1:2 to 1:4, but with the typical Western diet it’s more like 1:20.]

Abstract:
In osteoarthritis (OA) the synovium is often inflamed and inflammatory cytokines contribute to cartilage damage.

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have anti-inflammatory effects whereas omega-6 polyunsaturated fatty acids (omega-6 PUFAs) have, on balance, proinflammatory effects. The goal of our study was to assess the association of fasting plasma phospholipid omega-6 and omega-3 PUFAs with synovitis as measured by synovial thickening on contrast enhanced (CE) knee MRI and cartilage damage among subjects in the Multicenter Osteoarthritis Study (MOST).

MOST is a cohort study of individuals who have or are at high risk of knee OA. [The collaborative is tracking patients long-term “to identify factors that affect the occurrence and progression of osteo-arthritis related knee symptoms.”]

An unselected subset of participants who volunteered obtained CE 1.5 T MRI of one knee. Synovitis was scored in six compartments and a summary score was created. This subset also had fasting plasma, analyzed by gas chromatography for phospholipid fatty acid content, and non-CE MRI, read for cartilage morphology according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS) method.

The association between synovitis and cartilage morphology [structure] and plasma PUFAs was assessed using logistic regression after controlling for the effects of age, sex, and BMI.

472 out of 535 subjects with CE MRI had complete data on synovitis, cartilage morphology and plasma phospholipids. Mean age was 60 years, mean BMI 30, and 50% were women.

We found an inverse relation between total omega-3 PUFAs and the specific omega-3, docosahexaenoic acid [DHA] with patellofemoral cartilage loss, but not tibiofemoral cartilage loss or synovitis. [That is, the lower the omega-3s, the greater was the cartilage loss in the joint between the thigh bone and knee cap, and conversely the higher the omega-3 level, the less cartilage loss.]

A positive association was observed between the omega-6 PUFA, arachidonic acid, and synovitis. [Higher omega-6, more synovial inflammation.]

In conclusion, systemic levels of omega-3 and omega-6 PUFAs which are influenced by diet, may be related to selected structural findings in knees with or at risk of OA.

Future studies manipulating the systemic levels of these fatty acids may be warranted to determine the effects on structural damage in knee OA.

Source: Osteoarthritis and Cartilage, Feb 4, 2012. By Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, Grainger A, Nevitt MC, Clancy M, Lewis CE, Torner JC, Felson DT. Boston University Clinical Epidemiology Research and Training Unit, Tufts Jean Mayer Human Nutrition Research Center and Department of Radiology, and Boston University Medical Center, Boston, Massachusetts, USA; ULeeds, Leeds, United Kingdom; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA; Department of Preventive Medicine, University of Alabama, Birmingham, USA; Department of Epidemiology, University of Iowa, Iowa City, USA. [Email: krbaker@bu.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Immune Support Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
How I Found My Long-Lost Energy How I Found My Long-Lost Energy

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing