ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How Good Fats Prevent Heart Disease

Anti-inflammatory "No More Aches and Pains" Smoothie Bowl

The Bees' Best-Kept Secret: The Amazing Health Benefits of Propolis

Acupuncture: Why It Works

For women, healthy diets may help with mobility when aging

The Relationship Between Vitamin D and Insulin Resistance

High-Quality Whey Protein (in the Right Amounts) May Be Helpful for Weight Loss

8 Things to Consider for Depression

VIDEO: Living with Chronic Pain

Turmeric: The Spice of Life

 
Print Page
Email Article

Genetic evaluation of the serotonergic system in Chronic Fatigue Syndrome – Source: Psychoneuroendocrinology, Dec 11, 2007

  [ 69 votes ]   [ Discuss This Article ]
By AK Smith, et al. • www.ProHealth.com • December 15, 2007


Chronic Fatigue Syndrome (CFS) is a debilitating disorder of unknown etiology with no known lesions, diagnostic markers or therapeutic intervention. The pathophysiology of CFS remains elusive, although abnormalities in the central nervous system (CNS) have been implicated, particularly hyperactivity of the serotonergic (5-hydroxytryptamine; 5-HT) system and hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis.

Since alterations in 5-HT signaling can lead to physiologic and behavioral changes, a genetic evaluation of the 5-HT system was undertaken to identify serotonergic markers associated with CFS and potential mechanisms for CNS abnormality.

A total of 77 polymorphisms in genes related to serotonin synthesis (TPH2), signaling (HTR1A, HTR1E, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4, HTR5A, HTR6, and HTR7), transport (SLC6A4), and catabolism (MAOA) were examined in 137 clinically evaluated subjects (40 CFS, 55 with insufficient fatigue, and 42 non-fatigued, NF, controls) derived from a population-based CFS surveillance study in Wichita, Kansas.

  • Of the polymorphisms examined, three markers (-1438G/A, C102T, and rs1923884), all located in the 5-HT receptor subtype HTR2A, were associated with CFS when compared to NF controls.
  • Additionally, consistent associations were observed between HTR2A variants and quantitative measures of disability and fatigue in all subjects.
  • The most compelling of these associations was with the A allele of -1438G/A (rs6311) which is suggested to have increased promoter activity in functional studies.
  • Further, in silico analysis revealed that the -1438 A allele creates a consensus binding site for Th1/E47, a transcription factor implicated in the development of the nervous system. Electrophoretic mobility shift assay supports allele-specific binding of E47 to the A allele but not the G allele at this locus.
  • These data indicate that sequence variation in HTR2A, potentially resulting in its enhanced activity, may be involved in the pathophysiology of CFS.

    Source: Psychoneuroendocrinology. Dec 11 2007 [E-pub ahead of print] PMID: 18079067, by Smith AK, Dimulescu I, Falkenberg VR, Narasimhan S, Heim C, Vernon SD, Rajeevan MS. Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.





    Post a Comment

    Featured Products From the ProHealth Store
    Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    Natural Pain Relief Supplements

    Featured Products

    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium

    Natural Remedies

    Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
    Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
    Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
    Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
    How Glutathione Can Save Your Life How Glutathione Can Save Your Life

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE AND SAVE 15% NOW*
    Be the first to know about new products, special discounts and the latest health news. *New subscribers only

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map