ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Trial Finds Reduction in Depressive Symptoms Following Magnesium Supplementation

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

Carnitine deficiency suggested as contributor to autism

Vitamin D supplement use associated with lower risk of breast cancer

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Lutein — An Important Nutrient for Eye and Brain Health

 
Print Page
Email Article

B-cell alterations in ME/CFS ‘may suggest subtle tendency to autoimmunity’

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 4, 2012


Article:
Altered functional B-cell subset populations in patients with chronic fatigue syndrome compared to Healthy Controls
- Source: Clinical & Experimental Immunology, Nov 2012

By A.S. Bradley, B. Ford, A.S. Bansal

[Note: This article, abstracted below, is not yet available in formatted full text. The research took place at an NHS center serving ME/CFS patients in southwest London and Surrey.]

Abstract:
Chronic Fatigue Syndrome (CFS) is a heterogeneous disorder of unknown aetiology characterised by disabling fatigue, headaches, sleep disturbance and several other symptoms.

The onset of CFS may follow a viral infection or period of stress. Patients with CFS do not have hypogammaglobulinaemia, predisposition to recurrent bacterial infections or symptoms of autoimmunity.

To date, defects in B-cell numbers or function have not been shown in the literature. [In autoimmune disorders such as RA, immune B cells mistakenly attack self.] However, treatment with anti-B-cell therapy using Rituximab has recently shown benefit to CFS patients.

We therefore postulated that patients with CFS had a subtle humoral [found in the body fluids] immune dysfunction, and performed extended B-cell immunophenotyping.

We undertook a detailed characterization of the proportions of the different B-cell subsets in 33 patients with CFS fulfilling the Canadian and Fukuda criteria for CFS and compared these with 24 age and gender matched healthy controls (HC).

CFS patients had:

• Greater numbers of naïve B-cells as a % lymphocytes - 6.3 % versus 3.9 % in HC (P=0.034),

• Greater numbers of naïve B-cells as a % of B-cells - 65 % versus 47 % in controls (P=0.003),

• Greater numbers of transitional B-cells - 1.8 % versus 0.8 % in controls (P=0.025)

• And reduced numbers of plasmablasts - 0.5 % versus 0.9 % in controls (P=0.013).

While the cause of these changes is unclear, we speculate whether they may suggest a subtle tendency to autoimmunity.

Source: Clinical & Experimental Immunology, abstract online Nov 2012, full text article not yet formatted. DOI: 10.1111/cei.12043, by Bradley AS, Ford B, Bansal AS. Department of Immunology, St. Helier University Hospital NHS Trust, Carshalton, Surrey, UK. [Email: Amolak.Bansal@esth.nhs.uk]





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery
Safely Burn Away Body Fat Safely Burn Away Body Fat

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map