ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Guarding Against the Dangers of Vitamin D Deficiency

Omega-3 fatty acids, vitamin D may control brain serotonin, affecting behavior and psychiatric disor...

How Glutathione Can Save Your Life

New Dietary Guidelines Reverse Flawed Recommendations on Cholesterol

Long term antibiotic therapy may be an effective treatment for children co-morbid with Lyme disease ...

Beyond Depression... SAMe Broad-Spectrum Protection Against Disorders Of Aging

Anticancer Properties Of Saffron

BPA exposure linked to autism spectrum disorder, study reports

Omega-3 Fatty Acids Appear to Protect Damaged Heart After Heart Attack

Nine superfruits and super seeds to add to your diet

 
Print Page
Email Article

Gene Responsible for Most Malignant Melanomas is Discovered

  [ 39 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 24, 2002




By Mark Gould, London

Scientists working on the cancer genome project announced this week that they have made an "unexpectedly early" discovery of the mutant gene responsible for 70% of all malignant melanomas. The project, which is funded by the Wellcome Trust, is based at the Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire.

The researchers predict that the finding, which occurs in the early stages of a project involving 50 million experiments, will mean that the "vast majority" of the genes involved in the most common cancers will be identified within the next five years. The discovery is set to revolutionise cancer treatment, with the ability to target specific molecular abnormalities, they say.

The incidence of melanoma, which kills 1600 people a year in the United Kingdom and some 7400 in the United States, has doubled over the past decade. It is responsible for 11% of all skin cancers but almost all of the deaths from skin cancer because of its ability to metastasise rapidly.

The researchers, writing in the online version of Nature (www.nature.com), say that the mutation in the gene known as BRAF is "so clear cut" that they are five years away from offering drugs to block its action.

Scientists on the project began work in February 2001 to identify which of the 30000 human genes are involved in cancer. Professor Mike Stratton, one of the leaders of the project, said that the BRAF mutation was one of the first 20 they looked at.

"Because mutated BRAF is permanently `on,' we have already started searching for drugs that will switch it back off," Professor Stratton said. He said that slow computers were hampering progress to identify all the genetic components of all cancers.

But Professor Stratton said the consensus was that not all cancers shared one common genetic mutation. Project co-leader Dr Andy Futreal said that 1000 different human cancer samples, representing 43 different types of cancer, had been studied and that the initial results were "quite striking."

"Amongst the 2200 odd letters that go to encode the BRAF protein, one of those accounted for about 80% of all the mutations found. A single change, from a T to an A, in the spelling of the BRAF sequence will account for the mutation. It's extraordinarily specific."

The T to A switch in BRAF is also found in ABL, a gene found in myeloid leukaemia. This has been successfully treated with the new generation of tyrosine kinase inhibitors, such as imatinib (Glivec). The Wellcome Trust has now patented the gene to facilitate research on new treatments.

Source: BMJ 2002;324:1412 ( 15 June )



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Breaking Through the Mental Fog Breaking Through the Mental Fog
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing