ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Social Anxiety Disorder Linked to High Serotonin Levels, Throwing Treatment with SSRIs into Serious ...

A short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream surviva...

Can Botanicals Beat Brain Fog & Fibrofog?

Therapeutic Effects and Mechanisms of Action of Rifaximin in Gastrointestinal Diseases

Immune response to a flu vaccine yields new insights into narcolepsy

Promoting Optimal Nutrition with Digestive Enzymes

Omega-3 supplements and antioxidants may help with preclinical Alzheimer's disease

Children with Lyme Disease

Health Benefits of Ginseng

7-Keto DHEA The Fat-Burning Metabolite of DHEA

 
Print Page
Email Article

Gene Responsible for Most Malignant Melanomas is Discovered

  [ 39 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 24, 2002




By Mark Gould, London

Scientists working on the cancer genome project announced this week that they have made an "unexpectedly early" discovery of the mutant gene responsible for 70% of all malignant melanomas. The project, which is funded by the Wellcome Trust, is based at the Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire.

The researchers predict that the finding, which occurs in the early stages of a project involving 50 million experiments, will mean that the "vast majority" of the genes involved in the most common cancers will be identified within the next five years. The discovery is set to revolutionise cancer treatment, with the ability to target specific molecular abnormalities, they say.

The incidence of melanoma, which kills 1600 people a year in the United Kingdom and some 7400 in the United States, has doubled over the past decade. It is responsible for 11% of all skin cancers but almost all of the deaths from skin cancer because of its ability to metastasise rapidly.

The researchers, writing in the online version of Nature (www.nature.com), say that the mutation in the gene known as BRAF is "so clear cut" that they are five years away from offering drugs to block its action.

Scientists on the project began work in February 2001 to identify which of the 30000 human genes are involved in cancer. Professor Mike Stratton, one of the leaders of the project, said that the BRAF mutation was one of the first 20 they looked at.

"Because mutated BRAF is permanently `on,' we have already started searching for drugs that will switch it back off," Professor Stratton said. He said that slow computers were hampering progress to identify all the genetic components of all cancers.

But Professor Stratton said the consensus was that not all cancers shared one common genetic mutation. Project co-leader Dr Andy Futreal said that 1000 different human cancer samples, representing 43 different types of cancer, had been studied and that the initial results were "quite striking."

"Amongst the 2200 odd letters that go to encode the BRAF protein, one of those accounted for about 80% of all the mutations found. A single change, from a T to an A, in the spelling of the BRAF sequence will account for the mutation. It's extraordinarily specific."

The T to A switch in BRAF is also found in ABL, a gene found in myeloid leukaemia. This has been successfully treated with the new generation of tyrosine kinase inhibitors, such as imatinib (Glivec). The Wellcome Trust has now patented the gene to facilitate research on new treatments.

Source: BMJ 2002;324:1412 ( 15 June )



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Natural Relief for Soreness, Pain and Swelling – Putting Out the Fire
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing