ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Option For Chronic Fatigue Syndrome

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

Stop Bacteria With Nature's Antibiotics

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

New Test Shows Promise in Identifying New Drugs to Treat Lyme Disease

Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

Strengthen Cell Function with Energy-Boosting Niagen

Dietary Flavanols Reverse Age-Related Memory Decline

Vitamin D deficiency increases poor brain function after cardiac arrest by sevenfold

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

 
Print Page
Email Article

Seaweed Extract May Support “Very Significant” Improvement in Some FM Patients

  [ 417 votes ]   [ 1 Comment ]
By Editor • www.ProHealth.com • July 18, 2006


A recent randomized, placebo-controlled, double-blinded clinical study involving 29 diagnosed FM patients – 28 females and 1 male – concluded that supplementation over a period of eight weeks with the nutraceutical Fibronol™ offered statistically “very significant” average improvements in several key quality-of-life measures. These included sleep duration and quality, energy, and discomfort. Fibronol™ ’s primary ingredient is SEANOL-F, a polyphenol/phlorotannin extract of the brown seaweed Ecklonia cava.

Overall, 23 FM patients received daily doses of the supplement Fibronol™, and another 6 received a placebo (fake) dose. All subjects were also maintained on their current FM symptom-management regimens, which included a wide variety of prescription drugs and dietary supplements. Measures of patients’ quality of life factors, recorded at baseline, at two weeks for placebo patients, and at eight weeks, followed standard international guidelines for use in clinical trials involving FM patients.

Key Findings

At the end of eight weeks, the patients receiving Fibronol™ supplementation experienced, on average:
  • 1.6 additional hours of sleep per night
  • Deeper and less interrupted sleep, expressed as an 80 percent increase in sleep soundness
  • Accompanied by a 71 percent increase in energy, a 30 percent reduction in fatigue, and a 33 percent reduction in perceived discomfort level.
Each of these findings is statistically very significant, in that the probability it could have occurred by chance is less than 1 in 1,000 (P = < 0.001).

By comparison, the patients in the placebo group achieved no statistically significant improvements on these measures, and were switched during the course of the study to “open label” Fibronol™ supplementation.

Additionally, six of the patients receiving the Fibronol™ supplement who had a pre-existing condition of diarrhea experienced a worsening of the condition and were dropped from the study. The researchers speculate that this may be associated with the magnesium included as a secondary ingredient of Fibronol™, which is included for support of tissue repair. No other adverse effects were identified.

Specific Measures Employed

Measures of efficacy used in the study included:
  • A Pain Diary using the Visual Analogue Scale (VAS) pain score, which asks the patient to indicate intensities by marking positions on lines between two extremes.
  • The Brief Pain Inventory (BPI) pain assessment questionnaire.
  • The Patient Global Impression of Change (PGIC), a patient-reported periodic assessment of perception of change in their condition.
  • The Medical Outcomes Study (MOS) Sleep Scale, a 12-item self-report instrument that yields a summary score on sleep problems and detail on six sleep attribute scales.
  • The Multidimensional Fatigue Inventory (MFI), a 20-item self-report instrument designed to measure fatigue.
Other tests, to assess safety and identify potential adverse effects, included CBC blood serum chemistries, urinalysis, ECG, vital sign assessments, and adverse event records. All results were “normative to reduced” with the exception of increased diarrhea for the six patients with this pre-existing condition.

An abstract of the November 2005 study report, “Fibronol™ Phase 1-a Clinical Study,” by C. Palmer, PhD, et al., is available in pdf format at www.fibronol.com/fibronol_clinical_abstract.pdf

More Studies Ahead

This was a very small, preliminary (Phase I-a) study. The results seem to indicate that this natural food supplement may offer many people with FM promising support for improved quality of life. But larger, longer term studies will help to test and refine these preliminary findings. Fibronol LLC, the developer of Fibronol™ and its chief ingredient SEANOL-F – 14 years in development – has indicated plans for a Phase I-b study to run for six months.

Note:Fibronol LLC products are not intended to diagnose, treat, cure or prevent any disease.



Please Discuss This Article:   Post a Comment 

SAENOL-F
Posted by: debra m
Apr 30, 2009
I HAVE BEEN TAKING SEANOL-F FOR 3 WEEKS NOW AND I WILL ATTEST TO ITS ABILITY TO HAVE SIGNIFICAN RELIEF YO MY NERVES. ALTHOUGH I HAVE NOT BEEN DIAGNOSED WITH FIBROMYALGIA MY NEUROSURGEON PLACED ME ON LIRICA AND CYMBALTA DUE TO THE FACT THAT I DEVELOPED IMMEDIATELY AFTER SURGERY OF A HERNIATED DISK. MY SYATIC NERVE HAD BEEN PINCHED FOR 11 MONTHS AND NOW IT HAS BEEN 6 MONTHS SINCE MY SURGERY AND I AM JUST RECEIVING PHYSICAL THEREPY. (I'M HAVING TO DEAL WITH WORKER COMP IN ALL OF THIS, THAT IS WHY THINGS ARE NOT PROGRESSING AT A NORMAL RATE OF SPEED.) I HAD MADE THE DECISION TO TAKE MYSELF OFF FROM THE PRESCRIPTIONS OF LIRICA AND CYMBALTA, IN TURN I ASKED MY FAVORITE HEALTH FOOD STORE OWNER (GRADUATE OF HARVARD IN NUTRITION) AND SHE SUGGESTED SOMETHING THAT WAS NEW ON THE MARKET. FIBRONO AND OR FIBROBOOST. WHAT A DIFFERENCE IT HAS MADE IN MY LIFE. MY DAMAGE IS IN THE LEFT CALF. IT WAS COMPLETELY NUMB AND THE LEFT SIDE OF MY LEFT FOOT AND LAST TWO TOES (LEFT SIDE ALSO) HAS SHOOT PAINS THAT WHERE RUNNING UP THE FOOT ALL DAY LONG. I COULD NOT SLEEP FOR LONG ON MY BACK FOR BOTH ACHILLES HEELS WHERE BOTHERED WHEN MAKING CONTACT WITH THE MATTRESS. YES, I TRIED PLACING A PILLOW UNDER MY LEGS, TO NO AVAIL FOR IT IN TURN STARTED TO ACHE IN MY SPINE WITHIN MY MUSCLES (SPASMS). WHAT I WOULD LIKE TO KNOW IS HAS THERE BEEN STUDIES COMPLETED ON THE SIDE EFFECTS OF THAKING TO MUCH SEANOL-F? I HAVE DEVELOPED SOME COMPLICATIONS AND CUT THE DOSAGE IN HALF. I WAS TAKING BOTH OF THE ABOVE MENTIONED. EACH WAS TWO PILLS THREE TIMES A DAY. YES IT TOOK THE PAIN AWAY, HOWEVER NOW THAT I HAVE CUT IT IN HALF I STILL HAVE CONSTIPATION AT ITS WORST AND FLU LIKE SYSTOMS. NO I DO NOT HAVE THE SWINE FLU!! IN CUTTING THIS IN HALF MY PAIN IS BACK IN THE LEFT LEG AND FOOT AS WELL AS BOTH ACHILLES HEELS. PLEASE RESPOND TO THE QUESTION OF SIDE EFFECTS. THANK-YOU! DEBRA MAHONEY HOMOSASSA, FL.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Black Friday Sale

Featured Products

Fibronol® Fibronol®
A clinically tested, safe and effective nutraceutical for Fibromyalgia and CFS support
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Preserving Cognitive Function with Aging Preserving Cognitive Function with Aging
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing