Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The New Dual Activation Pain Relief Cream

SURVEY RESULTS: Medical Marijuana

Recipe: Mega-Golden Milk

Sweep Away Senile Cells

Vitamin D supplementation shows promise for Hashimoto's thyroiditis

A Paleolithic-type diet may help reduce future risk of diabetes and cardiovascular disease

Large whey protein breakfast may help manage type 2 diabetes

Decreased levels of vitamin D associated with reduced methylation in African American teens

Selenium — What Is it and Where Do I Get It?

Meta-analysis adds evidence to antidepressant effect for omega-3

 
Print Page
Email Article

A New Vitamin K Analysis Supports the Triage Theory: Modest Vitamin/Mineral Deficiencies Increase Age-Related Disease

  [ 81 votes ]   [ Discuss This Article ]
By Children’s Hospital & Research Center Oakland, CA • www.ProHealth.com • September 24, 2009


“Explains why diseases associated with aging like cancer, heart disease, and dementia (and the pace of aging itself) may be unintended consequences of mechanisms developed during evolution to protect against episodic vitamin/mineral shortages.”

An important analysis conducted by Children’s Hospital Oakland (CA) Research Institute scientists suggests the importance of ensuring optimal dietary intakes of vitamin K to prevent age-related conditions such as bone fragility, arterial and kidney calcification, cardiovascular disease, and possibly cancer.

Vitamin K is concentrated in dark green plants such as spinach or Swiss chard, and is either not present or present in only small amounts in most multivitamin pills. This finding comes from Associate Staff Scientist, Joyce McCann, PhD, and Senior Scientist, Bruce Ames, PhD, who analyzed data from hundreds of published articles dating back to the 1970’s.

Their review was designed to test Dr. Ames’ “triage” theory that provides a new basis for determining the optimum intake of individual vitamins and minerals (also called micronutrients), and has major implications for preventive medicine.

The analysis, which strongly supports his theory, is featured in the Oct 2009 issue of the American Journal of Clinical Nutrition.(1) [See “Vitamin K, an example of triage theory? Is micronutrient inadequacy linked to diseases of aging?”]

Dr. Ames proposed the triage theory in 2006 (2,3) to explain numerous observations from his own lab and the scientific literature. The theory explains why diseases associated with aging like cancer, heart disease, and dementia (and the pace of aging itself) may be unintended consequences of mechanisms developed during evolution to protect against episodic vitamin/mineral shortages. If correct, the triage theory has widespread implications for public health because modest vitamin/mineral deficiencies are quite common.

The theory also suggests a new scientifically based and consistent strategy for establishing optimal vitamin/mineral intake standards, and it provides a research strategy to uncover early biomarkers of chronic disease.

Vitamin K - much more than coagulation

• Vitamin K is known as the “Koagulation” vitamin because about half of the 16 known proteins that depend on vitamin K are necessary for blood coagulation.

• The other vitamin K-dependent proteins are involved in a variety of different functions involving the skeletal, arterial, and immune systems.

• Average intakes of vitamin K in the United States and the United Kingdom are less even than currently recommended intakes, which are primarily based (only) on levels to ensure adequate coagulation.

• McCann & Ames’ analysis supports recommendations by some experts that non-clotting functions requiring vitamin K may need higher intakes than are currently recommended.

McCann says, “Encouraging support for the triage theory from our vitamin K analysis suggests that experts aiming to set micronutrient intake recommendations for optimal function and scientists seeking mechanistic triggers leading to diseases of aging may find it productive to focus on micronutrient-dependent functions that have escaped evolutionary protection from deficiency.”

This vitamin K analysis is the first in a series of literature-based studies conducted by Drs. Joyce McCann and Ames to test the basic premises of the triage theory.

As a reviewer of the manuscript notes:
“…this review provides a unique perspective of consequences of vitamin K insufficiency and may serve as an important future reference, as new vitamin K-dependent proteins are identified and new (non-clotting) functions of vitamin K are elucidated. More broadly, an assessment of micronutrient sufficiency from the perspective of triage theory may provide a valuable point of view, as current recommendations for nutrient intakes are reconsidered.”
_____
References
1. McCann, J. C., and Ames, B. N. (2009) “Vitamin K, an example of triage theory: Is micronutrient inadequacy linked to diseases of aging?” AJCN 90 (4): Epub
2. Ames, B. N. (2006) “Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage.” PNAS 103, 17589-94.
3. Ames, B. N., and McCann, J. C. (2009) “Foreword: Prevention of cancer, and the other degenerative diseases of aging, through nutrition." In Chemoprevention of cancer and DNA damage by dietary factors. (Knasmuller S, DeMarini DM, Johnson I, Gerhauser C, eds), WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [This paper presents a short summary of the triage theory and the vitamin K analysis.]

Source: Children’s Hospital & Research Center Oakland, California, news release, Sep 16, 2009




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
20 Helpful Tips for Cleaning and Organizing When You're Chronically Ill

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map