ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Neuroimaging of Evoked Pain in Individuals with Fibromyalgia and Healthy Controls - Source: ACR/ARHP Scientific Meeting 2009, Oct 18, 2009

  [ 16 votes ]   [ Post a Comment ]
By Eric Ichesco, et al. • www.ProHealth.com • October 6, 2009

previous article next article

Purpose: Prior neuroimaging studies in fibromyalgia (FM) have identified augmented neuronal activity in response to evoked pain when compared to healthy controls (HC). Affected regions are largely contained within the pain matrix [regions in the brain that can be activated by pain alone], e.g., insula, thalamus, primary and secondary somatosensory cortex, anterior cingulate and the inferior parietal lobe).

To date, the majority of the functional magnetic resonance imaging (fMRI) studies in FM have been on a relatively small scale. Heterogeneity within FM as a disease state however suggests the need to replicate earlier findings in a larger sample.

Methods: 57 individuals (mean age 45) satisfying American College of Rheumatology criteria for FM and 20 healthy controls (mean age 42) were studied.

During a 10 min fMRI scan, 2 Kg. of pressure (mild pressure) was applied three times to the left thumbnail in random sequence for 25s. A 3-Tesla GE Sigma Scanner with neuro-optimized gradients (FOV = 22cm, T2* weighted, single shot, reverse spinal acquisition, GRE, TR = 2500, TE = 30, FA = 90, 64 x 64) was used to acquire fMRI data. Pre-processing and analysis of BOLD signal was performed using SPM2. Group level T statistical images were generated and uncorrected voxel level threshold of p<0.002 was used to identify significant activations.

Results:
In FM, 2 Kg. of pressure resulted in significant neural activity in:
• Insula (Z = 3.21).
• Bilateral inferior parietal lobes (BA 40, Z = 4.48-4.81),
• Primary somatosensory cortex (Z = 4.03)
• And secondary somatosensory cortex (Z = 4.69),
• Putamen (Z = 3.27)
• And caudate (Z = 3.24).

Additional activations were observed in:
• The cerebellum (Z = 4.95)
• And the middle frontal gyrus (Z = 4.37).

Healthy controls only had significant activation in the contralateral inferior parietal lobe (BA 40, Z = 3.18) using the same stimulus intensity.

Conclusion:
In contrast to healthy controls, mild pressure stimuli resulted in more extensive activation of pain matrix regions in individuals with FM.

This study reconfirms an augmented involvement of the “pain matrix” in the processing of evoked pain in FM and supports the role of central mechanisms being responsible for the pain of FM.

Source: ACR/ARHP Scientific Meeting 2009, Presentation # 89, Oct 18, 2009. (Fibromyalgia and Soft Tissue Disorders). Ichesco E, Bhavsar R, Harris R, Clauw D, Gracely R, Williams DA. University of Michigan, Ann Arbor, University of North Carolina, Chapel Hill.



previous article
  Rating 3.5 (16 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

FREE: Stop Feeding Yourself PAIN Guide [more]

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel sy... [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing