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Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract – Source: Journal of Neuroimmunology, May 26, 2010

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By Amit Gupta, et al. • www.ProHealth.com • June 14, 2010

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[Note: Olive leaf extract  is derived from the fruit, leaves, bark and roots of the olive tree. The active ingredient – oleuropein – makes all parts of the tree strongly resistant to disease, insect damage, and other factors. A component of oleuropein – elenoic acid – has been shown to support the body’s immune defense systems. In a previous paper, this team of pharmacologists & microbiologists reported the “significant antioxidative” effect of curcumin (turmeric) - another complex polyphenolic antioxidant compound - in an animal model of chronic fatigue syndrome.]
 
Various putative theories involved in the development of chronic fatigue syndrome revolve around the role of stress, infection and oxidative stress [free radical damage to cells]. Scientific evidence highlighting the protective role of nutritional supplements in chronic fatigue syndrome is lacking.

Based on these assumptions, the present study was designed to evaluate the effect of olive extract in a mouse model of immunologically-induced fatigue, wherein purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigen were used as immunogens.

The assessment of chronic fatigue syndrome was based on immobility period during chronic water-immersion stress test for 10 min daily. The stress-induced hyperalgesia was measured by tail withdrawal latency. Mice challenged with LPS or BA for 19 days showed significant increase in the immobility time, hyperalgesia and oxidative stress on the 19th day.

Serum tumor necrosis factor-alpha (TNF-a) levels were also markedly increased with LPS or BA challenge.

Concurrent treatment with olive extract resulted in a significant decrease in the immobility time as well as hyperalgesia. There was significant attenuation of oxidative stress as well as serum TNF-a levels. The results of the present study:

• Strongly indicate the role of oxidative stress and immunological activation in the pathophysiology of chronic fatigue syndrome

• And highlight the valuable role of olive extract in combating chronic fatigue syndrome.

Source: Journal of Neuroimmunology, May 26, 2010. PMID: 20537729, by Gupta A, Vij G, Chopra K. Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University, Chandigarh, India. [Email: dr_chopra_k@yahoo.com]



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