ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

Fish oil use associated with brain volume preservation

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Unsuspected aspect of immune regulation revealed: Role of B cells

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

Explaining 'Healthy' Obesity

Sinus Congestion and Sinusitis, Healing Naturally

Omega 3 Fatty Acids Lessen Severity of Osteoarthritis in Mice

In the gut, immunity is a two-way street

 
Print Page
Email Article

Epstein-Barr virus in bone marrow of rheumatoid arthritis patients predicts response to rituximab treatment – Source: Rheumatology (Oxford), Jun 14, 2010

  [ 36 votes ]   [ Discuss This Article ]
By M Magnusson, et al. • www.ProHealth.com • June 16, 2010


Objectives: Viruses may contribute to RA. This prompted us to monitor viral load and response to anti-CD20 therapy in RA patients. [The drug rituximab is an antibody against the protein CD20, found on the overactive B cells involved in the autoimmune activity of RA. In some patients, rituximab helps RA by depleting B cells.]

Methods: Blood and bone marrow from 35 RA patients were analysed for CMV (cytomegalovirus, a member of the herpes virus family), EBV (Epstein-Barr), HSV-1, HSV-2 (herpes simplex viruses), parvovirus B19 and polyomavirus using real-time PCR before and 3 months after rituximab (RTX) treatment and related to the levels of autoantibodies and B-cell depletion. [PCR – polymerase chain reaction – is a technique used to identify the presence of disease-causing viruses and/or bacteria.]

Clinical response to RTX was defined as decrease in the 28-joint disease activity score (DAS-28) of more than 1.3 at 6 months.

Results:

Before RTX treatment:

• EBV was identified in 15 out of 35 patients (EBV-positive group), of which 4 expressed parvovirus.

• Parvovirus was further detected in eight patients (parvo-positive group).

• Twelve patients were negative for the analysed viruses.

Following RTX:

• EBV was cleared, whereas parvovirus was unaffected.

• Eighteen patients were responders, of which 12 were EBV positive.

• The decrease in the DAS-28 was significantly higher in EBV-positive group compared with parvo-positive group (P = 0.002) and virus-negative patients (P = 0.04).

• Most of EBV-negative patients that responded to RTX (75%) required retreatment within the following 11 months compared with only 8% of responding EBV-positive patients.

• A decrease of RF, Ig-producing cells and CD19(+) B cells was observed following RTX but did not distinguish between viral infections.

• However, EBV-infected patients had significantly higher levels of Fas-expressing B cells at baseline as compared with EBV-negative groups.

Conclusions:

EBV and parvovirus genomes are frequently found in bone marrow of RA patients.

The presence of EBV genome was associated with a better clinical response to RTX.

Thus, presence of EBV genome may predict clinical response to RTX.

Source: Rheumatology, Jun 14, 2010. Magnusson M, Brisslert M, Zendjanchi K, Lindh M, Bokarewa MI. Department of Rheumatology and Inflammation Research and Department of Virology, Sahlgrenska University Hospital, Göteborg, Sweden.





Discuss This Article Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing