Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Single Low-magnitude Electric Pulse Successfully Fights Inflammation

Why Is Spicy Food Good for You?

Parasites and Worms As Major Complicating Co-Factors In Lyme Disease Recovery

12 Celebrities with Lyme Disease

Omega-3 fatty acids may help improve treatment, quality of life in cancer patients

How Essential Oils Can Help Improve Your Life

Ask the Doctor- Is it possible to be fully healed from or cured of Lyme Disease?

Clinically Studied Joint Relief Product for FM & ME/CFS

Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteoli...

 
Print Page
Email Article

Flupirtine in Pain Management: Pharmacological Properties and Clinical Use – Source: CNS Drugs, Oct 2010

  [ 8 votes ]   [ Discuss This Article ]
By Jacques Devulder • www.ProHealth.com • December 7, 2010


[Note: for more information on flupirtine - a non-NSAID, non-opioid pain drug - which is prescribed by a number of brand names in Europe and is not FDA approved in the US though trials are planned, see Drugs.com International .www.drugs.com/international/flupirtine-maleate.html.

Flupirtine is a centrally acting, non-opioid analgesic that is available in a number of European countries for the treatment of a variety of pain states.

The therapeutic benefits seen with flupirtine relate to its unique pharmacological properties. Flupirtine displays indirect NDMA receptor antagonism via activation of potassium channels and is the first representative of a pharmacological class denoted the ‘selective neuronal potassium channel openers’.

The generation of the M-current is facilitated by flupirtine via the opening of neuronal Kv7 potassium channels. The opening of these channels inhibits exaggerated neuronal action potential generation and controls neuronal excitability.

Neuronal hyperexcitability is a physiological component of many pain states such as chronic pain, migraine and neurogenic pain.

Although large-scale clinical trials are lacking, the clinical trial database available to date from smaller-scale studies, together with extensive clinical experience, indicate that flupirtine effectively reduces chronic musculoskeletal pain, migraine and neuralgias, amongst other types of pain.

In addition, flupirtine produces, at recommended clinical doses, muscle-relaxing effects in the presence of abnormally increased muscle tension. Its analgesic and muscle-relaxant properties were comparable to tramadol and chlormezanone, respectively, in two prospective trials in patients with lower back pain.

Cytoprotective, anti-apoptotic and antioxidant properties have also been associated with flupirtine use in a small number of studies to date.

When provided as combination therapy with morphine, flupirtine increases the antinociceptive activity of morphine 4-fold.

Flupirtine displays superior tolerability when compared with tramadol and pentazocine.

The most common adverse effects associated with flupirtine use are drowsiness, dizziness, heartburn, dry mouth, fatigue and nausea.

With respect to its molecular structure, mechanism of action and adverse event profile, flupirtine is a unique drug. Flupirtine is an analgesic with many potential therapeutic benefits that may prove useful in the treatment of many disease states.

Source: CNS Drugs, Oct 2010. Volume 24 - Issue 10 - pp 867-881. PMID: 20839897, by Devulder, J. Department of Anaesthesia, Section Pain Clinic, Ghent University Hospital, Ghent, Belgium. [Email: jacques.devulder@ugent.be].  



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Breaking Through the Mental Fog Breaking Through the Mental Fog
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing