ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

 
Print Page
Email Article

Antibiotic Selectively Prevents Prostate Cancer Cell Growth – 1 of 5,000 Drugs Tested by Finnish Researchers

  [ 12 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 20, 2010


Researchers from VTT Technical Research Centre of Finland and the University of Turku have demonstrated that an antibiotic called “monensin” prevents the growth of prostate cancer cells. Monensin is used in the meat and dairy industry, for example. [Note: Monensin is an antibiotic most widely used to prevent the parasitic intestinal disease coccidiosis, common throughout the world and often transmitted among farm and kennel raised animals via feed and water.]

Evidence pointing to the effects of monensin emerged in a project investigating the effects of nearly 5,000 drugs and micromolecules on the growth of prostate cancer cells. The project involved most of the drugs on the market today.

Researchers found that:

• Small amounts of compounds – disulfiram (Antabus), thiram, tricostatin A, and monensin – can prevent the growth of prostate cancer cells without significant effects on the growth of the normal human prostate epithelial cells.

• Further studies revealed that monensin caused prostate cancer cell death by reducing the amount of testosterone receptor and by increasing production of reactive oxygen species and inducing DNA damage.

• In addition, monensin was shown to have combined effects with anti-androgens – the drugs suppressing the effects of androgens – in preventing prostate cancer cell growth.

“These research findings give rise to a potential new use for the monensin. The results also demonstrate that the effects of anti-androgens in suppressing the growth of cancer cells can be enhanced by using drugs inducing production of reactive oxygen species”, say Senior Research Scientist Kristiina Iljin from VTT and Research Scientist Kirsi Ketola from the University of Turku.

The research findings concerning the effects of drugs and micromolecules were published by Clinical Cancer Research in 2009. The effects of monensin on preventing the growth of prostate cancer was published by Molecular Cancer Therapeutics in December 2010.(1)

Recently, medical companies have shown great interest in these kinds of projects aiming at finding novel indications for established drugs.

Since the dosage and adverse effects of drugs already in use and their combined effects with other drugs are relatively well known, this kind of drug repositioning may result in considerable cost savings.

Prostate cancer is the second most common cause of cancer death in men after lung cancer. It has been estimated that globally about 300,000 men die from prostate cancer every year.
___
1. “Monensin is a Potent Inducer of Oxidative Stress and Inhibitor of Androgen signaling Leading to Apoptosis in Prostate Cancer Cells,” Molecular Cancer Therapeutics, Dec 2010, by Ketola K, Lljin K, et al.

Source: VTT Technical Research Centre of Finland, press release, Dec 20, 2010



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
"It's Not Easy Being Green" - But It Is Healthy
VIDEO: Healthy Eating and Fibromyalgia VIDEO: Healthy Eating and Fibromyalgia
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing