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Delirium secondary to pregabalin – Source: General Hospital Psychiatry, Dec 15, 2011

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By Catherine Hickey, MD, Barbara Thomas, PharmD • www.ProHealth.com • December 21, 2011


[Note: Delirium is sudden onset of severe confusion, disrupted attention/memory, and quick changes between mental states (e.g., from agitated to lethargic). It is usually temporary and reversible and often results when the brain is deprived of oxygen or other substances.]

Fibromyalgia is a common and disabling disease, and treatment can be challenging. More recently, pregabalin [brand name Lyrica®] has been approved to treat pain associated with fibromyalgia. However, it can have serious neuropsychiatric sequelae.

Several case reports have documented delirium secondary to pregabalin, usually in older patients with multiple medical comorbidities and concurrent medications. We describe a case of delirium in a young patient without significant medical problems and in the absence of other potentially causal medications.

In this case, pregabalin appears to be the single causal etiology for delirium.

We recommend clinicians to consider the causal role it may play in any patient who presents with delirium.

Source: General Hospital Psychiatry, Dec 15, 2011. Hickey C, Thomas B. Memorial University of Newfoundland, Geriatric Psychiatry Day Hospital; Waterford Hospital, Memorial University School of Pharmacy, St. John's, NL, Canada.



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