Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The New Dual Activation Pain Relief Cream

The Importance of B Vitamins for Brain Health and Combating Dementia

SURVEY RESULTS: Medical Marijuana

High serum omega-6 polyunsaturated fatty acid concentrations linked to lower risk of type 2 diabetes

Recipe: Mega-Golden Milk

Vitamin D supplementation shows promise for Hashimoto's thyroiditis

A Paleolithic-type diet may help reduce future risk of diabetes and cardiovascular disease

Large whey protein breakfast may help manage type 2 diabetes

Meta-analysis adds evidence to antidepressant effect for omega-3

Higher vitamin C intake may help slow cataract progression

 
Print Page
Email Article

Greater arthritic knee inflammation & damage associated with lower serum omega-3

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 9, 2012


Article:
Association of plasma omega-6 and omega-3 polyunsaturated fatty acids with synovitis in the knee: The MOST study
- Source: Osteoarthritis and Cartilage, Feb 4, 2012

By Kristin R Baker, et al.

[Note: Synovium is a thin layer of cells lining the joints and joint-stabilizing tendons, which when healthy produces joint lubricating synovial fluid. The ideal omega-3 to omega-6 ratio is thought to be 1:2 to 1:4, but with the typical Western diet it’s more like 1:20.]

Abstract:
In osteoarthritis (OA) the synovium is often inflamed and inflammatory cytokines contribute to cartilage damage.

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have anti-inflammatory effects whereas omega-6 polyunsaturated fatty acids (omega-6 PUFAs) have, on balance, proinflammatory effects. The goal of our study was to assess the association of fasting plasma phospholipid omega-6 and omega-3 PUFAs with synovitis as measured by synovial thickening on contrast enhanced (CE) knee MRI and cartilage damage among subjects in the Multicenter Osteoarthritis Study (MOST).

MOST is a cohort study of individuals who have or are at high risk of knee OA. [The collaborative is tracking patients long-term “to identify factors that affect the occurrence and progression of osteo-arthritis related knee symptoms.”]

An unselected subset of participants who volunteered obtained CE 1.5 T MRI of one knee. Synovitis was scored in six compartments and a summary score was created. This subset also had fasting plasma, analyzed by gas chromatography for phospholipid fatty acid content, and non-CE MRI, read for cartilage morphology according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS) method.

The association between synovitis and cartilage morphology [structure] and plasma PUFAs was assessed using logistic regression after controlling for the effects of age, sex, and BMI.

472 out of 535 subjects with CE MRI had complete data on synovitis, cartilage morphology and plasma phospholipids. Mean age was 60 years, mean BMI 30, and 50% were women.

We found an inverse relation between total omega-3 PUFAs and the specific omega-3, docosahexaenoic acid [DHA] with patellofemoral cartilage loss, but not tibiofemoral cartilage loss or synovitis. [That is, the lower the omega-3s, the greater was the cartilage loss in the joint between the thigh bone and knee cap, and conversely the higher the omega-3 level, the less cartilage loss.]

A positive association was observed between the omega-6 PUFA, arachidonic acid, and synovitis. [Higher omega-6, more synovial inflammation.]

In conclusion, systemic levels of omega-3 and omega-6 PUFAs which are influenced by diet, may be related to selected structural findings in knees with or at risk of OA.

Future studies manipulating the systemic levels of these fatty acids may be warranted to determine the effects on structural damage in knee OA.

Source: Osteoarthritis and Cartilage, Feb 4, 2012. By Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, Grainger A, Nevitt MC, Clancy M, Lewis CE, Torner JC, Felson DT. Boston University Clinical Epidemiology Research and Training Unit, Tufts Jean Mayer Human Nutrition Research Center and Department of Radiology, and Boston University Medical Center, Boston, Massachusetts, USA; ULeeds, Leeds, United Kingdom; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA; Department of Preventive Medicine, University of Alabama, Birmingham, USA; Department of Epidemiology, University of Iowa, Iowa City, USA. [Email: krbaker@bu.edu]





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Aching for Pain Relief?

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map