Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Big step towards cure for HIV and other lifelong viral infections

SURVEY RESULTS: Attitudes About Fatigue

Superfood Trio: Ginger, Turmeric, and Carrots?

Rejuvenate Your Skin Naturally With Sea Buckthorn Oil

Can Drinking More Water Help You Lose Weight?

Resveratrol’s Link to Slowing Alzheimer’s

Tropical Turmeric Carrot Juice & Smoothie

Most Everyone Can Use More Vitamin D

Omega-3s May Improve Healing After a Heart Attack

Scientists discover potential avenue to treating type 2 diabetes at early stages

 
Print Page
Email Article

Analgesics are More Effective with Caffeine Chaser, Study Finds

  [ 6 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 21, 2012


Article:
Caffeine as an analgesic adjuvant for acute pain in adults
- Source: Cochrane Database of Systematic Reviews, Mar  2012

By Christopher J Derry, Sheena Derry, R Andrew Moore

[Note: Cochrane reviews are evaluations of medical research meant to support healthcare decisions based on the best current evidence. To read the full text pdf of this article, click HERE and select ‘read review.’ Or listen to an audio introduction/summary by selecting ‘play now.’ According to the audio, adding 100mg of caffeine - equivalent of a mug of coffee – gives good pain relief for 5% to 10% more people, and that percentage went up in studies testing doses of 200mg, etc. Reasons? Caffeine hastens analgesic absorption from the stomach but is also somehow analgesic in its own right. The article gives results for the different drug & caffeine combos tested.]

Abstract:
Background: Caffeine has been added to common analgesics such as paracetamol, ibuprofen, and aspirin, in the belief that it enhances analgesic efficacy. Evidence to support this belief is limited and often based on invalid comparisons.

Objectives: To assess the relative efficacy in acute pain of a single dose of any analgesic plus caffeine against the same dose of analgesic alone.

Search methods: We searched CENTRAL, MEDLINE, EMBASE, and the Oxford Pain Relief Database to January 2012, and also carried out Internet searches and contacted pharmaceutical companies known to have carried out trials that have not been published.

Selection criteria: We included randomized, double-blind studies that compared a single dose of analgesic plus caffeine with the same dose of the analgesic alone in the treatment of acute pain.

Data collection and analysis: Two review authors independently assessed eligibility and quality of studies, and extracted data. Any disagreements or uncertainties were settled by discussion with a third review author.

We sought any validated measure of analgesic efficacy, but particularly the number of:

• Participants experiencing at least 50% of the maximum possible pain relief over four to six hours,

• Participants reporting a global evaluation of treatment of very good or excellent,

• Or headache relief after two hours.

We pooled comparable data to look for a statistically significant difference, and calculated numbers needed to treat to benefit (NNT) with caffeine.

We also looked for any numerical superiority associated with the addition of caffeine, and information about any serious adverse events.

Main results: We identified 19 studies (7,238 participants) in valid comparisons. Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache.

There was a small but statistically significant benefit with caffeine used at doses of 100 mg or more, which was not dependent on the pain condition or type of analgesic.

About 5% to 10% more participants achieve a good level of pain relief (at least 50% of the maximum) with the addition of caffeine, giving a NNT of about 15. [That is, taking caffeine with their analgesic would enable 1 more person in a group of 10 or 15 to reduce pain by 50% or better.]

Source: Cochrane Database of Systematic Reviews, Mar  2012. DOI: 10.1002/14651858.CD009281.pub2, by Derry CJ, Derry S, Moore RA. Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford; Pain Research Unit, Churchill Hospital, Oxford, UK. [Email: sheena.derry@pru.ox.ac.uk]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map