ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

 
Print Page
Email Article

Research highlights IBS drugs offering best risk-benefit odds

  [ 12 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 26, 2012


Based on analysis of more than two dozen major clinical trials, two well-studied drug therapies – rifaximin and lubiprostone – offer irritable bowel syndrome (IBS) patients the best odds of benefit without harmful side effects, according to research led by the GI Motility Lab at Cedars-Sinai Medical Center in New York.

Led by Motility Lab Director Mark Pimentel, MD, the team published their findings online Mar 26 in The American Journal of Medicine.

“For the millions of patients who suffer from IBS [one in five US adults], effective treatment options have been very scarce,” Dr. Mark Pimentel says. Patients with IBS may experience a diarrheal form of the condition, a constipational form, or some combination, he explains. Frequent symptoms include abdominal pain or cramps, excess gas or bloating and visible abdominal distension.

Many Therapies Involve Side Effects

But drug therapies employed to treat IBS cause troubling side effects of their own, including nausea, insomnia, palpitations and decreased appetite. In an effort to sort out which treatments may provide benefits with the least risk of harm, the Cedars-Sinai team reviewed and compared the results of dozens of large-scale IBS drug trials.

For diarrhea forms of the condition, they evaluated:

• Tricyclic antidepressants;

• Alosetron, a drug that slows movement of stool in the gut;

• And rifaximin, an antibiotic that stays in the gut rather than disseminating into the blood stream and is currently FDA-approved to treat traveler’s diarrhea and hepatic encephalopathy.

For constipation forms of IBS, the researchers examined:

• Antidepressants known as serotonin reuptake inhibitors and

lubiprostone, a drug that promotes gut secretion.

The Research Found Striking Differences

On the one hand:

•  For every 2.3 patients who benefited from tricyclic antidepressants, 1 suffered harmful side effects and had to stop taking the medication.

•  For every 2.6 patients helped by alosetron, 1 had to halt the drug.

By contrast:

•  For every 846 patients aided by rifaximin, 1 had to discontinue the medication.

•  Lubiprostone and serotonin reuptake inhibitors demonstrated a complete lack of “harm” to IBS patients with constipation, as defined by the study.

“We found that rifaximin and lubiprostone have the lowest level of harmful side effects of all the well-studied drug therapies for IBS,” says Dr. Pimentel. “This underscores the need for us to continue to monitor new therapies for this disease,” he adds. “While it is important to see benefit with drugs, harm is something we do not often assess well."

Besides Cedars-Sinai, other centers participating in the research included the School of Medicine at Texas Tech University’s Health Sciences Center; the UCLA Department of Medicine; Beth Israel Deaconess Medical Center; and Harvard Medical School. Funding for the study was provided by the Beatrice and Samuel A. Seaver Foundation.

The researchers note that: Dr. Pimentel discovered the use of rifaximin for IBS. Cedars-Sinai holds patent rights to the discovery and has a licensing agreement with Salix Pharmaceuticals Inc., which markets the drug. Dr. Pimentel is a consultant to Salix and serves on its scientific advisory board. None of the authors is affiliated with lubiprostone maker Takeda Pharmaceuticals or other drugs that were evaluated.

Source: Based on Cedars-Sinai Medical Center press release, Mar 26, 2012



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
"It's Not Easy Being Green" - But It Is Healthy
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing