Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

12 Celebrities with Lyme Disease

Sexual Transmission of Lyme Disease: a Paradigm Shift

Single Low-magnitude Electric Pulse Successfully Fights Inflammation

Why Is Spicy Food Good for You?

Omega-3 fatty acids may help improve treatment, quality of life in cancer patients

How Essential Oils Can Help Improve Your Life

Parasites and Worms As Major Complicating Co-Factors In Lyme Disease Recovery

Ask the Doctor- Is it possible to be fully healed from or cured of Lyme Disease?

Anti-histamine drug Claritin can kill Borrelia by interfering with manganese utilization

 
Print Page
Email Article

Kansas Clinic's Patented Test Measures Energy Metabolism in Chronic Fatigue Syndrome

  [ 7 votes ]   [ 1 Comment ]
www.ProHealth.com • April 11, 2012


 Article:
The Assessment of the Energy Metabolism in Patients with Chronic Fatigue Syndrome by Serum Fluorescence Emission
- Source: Alternative Therapies in Health and Medicine, Jan-Feb 2012

By Nina Mikirova, Joseph Casciari, Ronald Hunninghake

[Note: The fatigue marker discussed here is NAD(P)H, the reduced form of the coenzyme NADP. It can be measured via the level of its fluorescence when blood serum is irradiated. In a previous study these researchers found that lower concentrations of NAD(P)H were indicative of reduced energy metabolism in cancer patients. The full text PDF of this article is available free at www.riordanclinic.org/research/articles/AT-2012-v18.pdf.]

Context: Chronic fatigue syndrome (CFS) is a debilitating fatigue illness that has unknown etiology and lacks an objective diagnostic marker.

Objective: To examine the metabolic component of CFS to determine if practitioners can use serum NAD(P)H concentration measurements to monitor metabolism and fatigue status in patients with CFS.

Design: The research team conducted a case-control study, comparing a group of patients who were diagnosed with CFS with a control group of healthy subjects. The team obtained venous blood samples from fasting patients to examine the serum NAD(P)H concentrations.

Setting: The study occurred at the Riordan Clinic in Witchita, Kansas.

Participants: The study included 44 CFS patients at the Riordan Clinic and 30 healthy control participants.

The CFS patients presented a spectrum of symptoms that had existed for at least 6 months: new, unexplained, persistent, or relapsing chronic fatigue that bed rest did not resolve and that was severe enough to reduce daily activity significantly - by 50% - in conjunction with headache, muscle pain, pain in multiple joints, and unrefreshing sleep.

In the control group, the research team enrolled subjects without diagnosis of disease or injury.

Outcome Measures: The research team determined levels of serum reduced nicotinamide adenine dinucleotides (NADH and NAD[P]H) by measuring serum fluorescence emission at 450 nm. The team then conducted sensitivity and specificity analyses.

Results:
• NAD(P)H concentrations in serum of CFS participants averaged 8.0 +/- 1.4 (standard deviation [SD]) nmol/mL,

• While those in the healthy controls averaged 10.8 +/- 0.8 (SD) nmol/mL, a statistically significant difference.

Using a cut-off concentration of 9.5 nmol/mL, the research team attained a sensitivity of 0.73 and a specificity of 1.0. An analysis of receiver-operator characteristics yielded an area under the curve of 0.9.

The research team compared serum NAD(P)H to several endocrine and metabolic lab parameters. Serum NAD(P)H was directly correlated with serum CoQ10 levels and inversely correlated with urine hydroxyhemopyrrolin-2-one levels.

Conclusions: Based on these findings, the research team proposed using serum NAD(P)H, measured as an intrinsic serumfluorescence emission, to monitor metabolism and fatigue status in patients with CFS.

Following patients’ NAD(P)H levels over time may aid in selecting therapeutic strategies and monitoring treatment outcomes.

Source: Alternative Therapies, Jan-Feb 2012;18(1):36-40. ISSN#10786791 Mikirova N, Casciari J, Hunninghake R. Riordan Clinic, Wichita, Kansas, USA. [Email: nmikirova@riordanclinic.org]




Please Discuss This Article:   Post a Comment 

Objective test?
Posted by: KerryK
Apr 11, 2012
Wouldn't this qualify as an objective test?
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Prepare Yourself for Cold & Flu Season

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing