ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Inflammatory fatigue and sickness behavior - Lessons for the diagnosis and management of chronic fatigue syndrome – Source: Journal of Affective Disorders, May 11, 2012

  [ 9 votes ]   [ Post a Comment ]
By Simon V. Arnett, IA Clark • www.ProHealth.com • May 15, 2012

previous article next article

[Ed note: given the brevity of the abstract offered below, co-author Simon Arnett has kindly provided the following outline of key concepts that the full text article explores:

“This review is an attempt to provide an overview of what is known about the changes that occur in CFS, and how these changes might be explained by an inflammatory process. This explanation draws on what is known about a process called 'cytokine-mediated sickness behavior'.

Sickness behavior is a very well studied cluster of neurological and behavioral changes that occur when the brain is exposed to increased inflammatory mediators, and is similar in many regards to CFS.

“It is therefore argued that CFS may be a syndrome in which the normal processes of sickness behavior malfunction to produce the debilitating lived experience of CFS.

“This review also discusses the search for a blood test for CFS. This discussion focuses on a test for increased oxidation, which has been proposed by several other authors. However, using this blood test could be dangerous, as it cannot distinguish chronic fatigue syndrome from other conditions such as cancer and autoimmune disease, which can cause symptoms very similar to CFS.

“Finally, the review argues that if CFS is the result of a similar process that produces cytokine mediated sickness behavior, then targeting this process with anti-cytokine therapy (using drugs such as etanercept and anakinra) should be effective in improving patient symptoms."]

Abstract:
Persistent and severe fatigue is a common part of the presentation of a diverse range of disease processes. There is a growing body of evidence indicating a common inflammatory pathophysiology underlying many conditions where fatigue is a primary patient concern, including chronic fatigue syndrome.

This review explores current models of how inflammatory mediators act on the central nervous system to produce fatigue and sickness behavior, and the commonality of these processes in conditions as diverse as surgical trauma, infection, various cancers, inflammatory bowel disease, connective tissue diseases and autoimmune diseases.

We also discuss evidence indicating chronic fatigue syndrome may have important pathophysiological similarities with cytokine mediated sickness behavior, and what lessons can be applied from sickness behavior to chronic fatigue syndrome with regards to the diagnosis and management.

Source: Journal of Affective Disorders, May 11, 2012. Arnett SV, Clark IA. Research School of Biology, Australian National University, Canberra, Australia. [Email: simon.arnett@anu.edu.au]



previous article
  Rating 4.1 (9 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

FREE: Stop Feeding Yourself PAIN Guide [more]

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel sy... [more]

EBV I: A Deficient Immune Response, Increased Levels of Epstein-Barr Virus Opens Up EBV Question in ... [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing