Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

High dose vitamin D3 supplementation lowers inflammatory T cells in multiple sclerosis patients

Chocolate's Potential Health Benefits – and its Effect on Chronic Fatigue Syndrome Patients

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Essential Oils - How and Where to Use Them

The Link Between Vitamin C And Optimal Immunity

SURVEY: What Is Your Diagnosis?

What's So Great About Grape Seed?

Why Does Your Nose Run When It's Cold Outside?

Study suggests that what you eat can influence how you sleep

How Your Mitochondria Influence Your Health

 
Print Page
Email Article

Inflammatory fatigue and sickness behavior - Lessons for the diagnosis and management of chronic fatigue syndrome – Source: Journal of Affective Disorders, May 11, 2012

  [ 9 votes ]   [ Discuss This Article ]
By Simon V. Arnett, IA Clark • www.ProHealth.com • May 15, 2012


[Ed note: given the brevity of the abstract offered below, co-author Simon Arnett has kindly provided the following outline of key concepts that the full text article explores:

“This review is an attempt to provide an overview of what is known about the changes that occur in CFS, and how these changes might be explained by an inflammatory process. This explanation draws on what is known about a process called 'cytokine-mediated sickness behavior'.

Sickness behavior is a very well studied cluster of neurological and behavioral changes that occur when the brain is exposed to increased inflammatory mediators, and is similar in many regards to CFS.

“It is therefore argued that CFS may be a syndrome in which the normal processes of sickness behavior malfunction to produce the debilitating lived experience of CFS.

“This review also discusses the search for a blood test for CFS. This discussion focuses on a test for increased oxidation, which has been proposed by several other authors. However, using this blood test could be dangerous, as it cannot distinguish chronic fatigue syndrome from other conditions such as cancer and autoimmune disease, which can cause symptoms very similar to CFS.

“Finally, the review argues that if CFS is the result of a similar process that produces cytokine mediated sickness behavior, then targeting this process with anti-cytokine therapy (using drugs such as etanercept and anakinra) should be effective in improving patient symptoms."]

Abstract:
Persistent and severe fatigue is a common part of the presentation of a diverse range of disease processes. There is a growing body of evidence indicating a common inflammatory pathophysiology underlying many conditions where fatigue is a primary patient concern, including chronic fatigue syndrome.

This review explores current models of how inflammatory mediators act on the central nervous system to produce fatigue and sickness behavior, and the commonality of these processes in conditions as diverse as surgical trauma, infection, various cancers, inflammatory bowel disease, connective tissue diseases and autoimmune diseases.

We also discuss evidence indicating chronic fatigue syndrome may have important pathophysiological similarities with cytokine mediated sickness behavior, and what lessons can be applied from sickness behavior to chronic fatigue syndrome with regards to the diagnosis and management.

Source: Journal of Affective Disorders, May 11, 2012. Arnett SV, Clark IA. Research School of Biology, Australian National University, Canberra, Australia. [Email: simon.arnett@anu.edu.au]




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing