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Predictors of post-infectious chronic fatigue syndrome in adolescents

  [ 4 votes ]   [ 1 Comment ]
By Leonard A. Jason at al. • • February 15, 2014

Note: You can read the full article HERE.

By Leonard A. Jason et al.
This study focused on identifying risk factors for adolescent post-infectious chronic fatigue syndrome (CFS), utilizing a prospective, nested case–control longitudinal design in which over 300 teenagers with infectious mononucleosis (IM) were identified through primary care sites and followed.
Baseline variables that were gathered several months following IM, included autonomic symptoms, days in bed since IM, perceived stress, stressful life events, family stress, difficulty functioning and attending school, family stress, and psychiatric disorders.
A number of variables were predictors of post-infectious CFS at six months; however, when autonomic symptoms were used as a control variable, only days spent in bed since mono was a significant predictor.
Step-wise logistic regression findings indicated that baseline autonomic symptoms as well as days spent in bed since mono, which reflect the severity of illness, were the only significant predictors of those who met CFS criteria at six months.

Source: Leonard A. Jason, Ben Z. Katz, Yukiko Shiraishi, Cynthia J. Mears, Young Im & Renee R. Taylor. Health Psychology and Behavioral Medicine: An Open Access Journal Volume 2, Issue 1, 2014

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Article Comments Post a Comment

Great study
Posted by: IanH
Feb 15, 2014
I do hope Prof. Jason and his team continue this work into ME/CFS post IM. I would also be worth looking at other variables which may affect who goes on to develop ME/CFS after IM.

For example:
Vitamin D status.
Because vitamin D is immunomodulatory, those with low vitamin D levels at the time of infection will have a more severe form of the illness and since illness severity is the biggest predictor of ME/CFS perhaps vitamin D status is a predictor.

Low vitamin D status during childhood causes increased antibodies to thyroid and subsequent thyroid function. Most people with ME/CFS have some thyroid dysfunction and their symptoms reflect that. Poorer thyroid function during an illness such as IM would probably also result in higher severity of illness and consequently higher risk of ME/CFS
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