Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Netwo...

Lyme Camp- A Unique Event for People with Lyme Disease

International Lyme and Associated Diseases Society Hosts Its Annual Scientific Conference in Ft. Lau...

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Acupuncture reduces hot flashes in breast cancer survivors

Top 7 Nutrient-Dense Foods That Make Calorie Counting Obsolete

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

Magnificent Milk Thistle

SURVEY: Has Your Illness Affected What You Eat?

DePaul Study Recruiting Participants

Print Page
Email Article

Prozac May Offer Short-Term Fibromyalgia Relief

  [ 101 votes ]   [ Discuss This Article ] • March 21, 2002

Mar 21, 1:12 PM ET

NEW YORK (Reuters Health) - Women with fibromyalgia experienced modest improvements in their condition after taking the antidepressant Prozac (fluoxetine) for 3 months, according to the results of a recent study.

Fibromyalgia is a chronic condition, often accompanied by depression and fatigue, in which a person feels pain in the muscles and tissues surrounding the joints. While the cause of fibromyalgia is unknown, researchers have found pain-processing abnormalities in the spines and brain stems of those with fibromyalgia.

About 2% of the US population is estimated to suffer from fibromyalgia, mostly women aged 50 years and older.

While previous studies of the effectiveness of antidepressants in patients with fibromyalgia have had mixed results, a report published in The American Journal of Medicine suggests that the dosages used in those studies may have been too low.

In the current study, Dr. Lesley M. Arnold of the University of Cincinnati Medical Center in Ohio and colleagues evaluated 51 non-depressed women with fibromyalgia. Twenty-five of the women took an average of 50 milligrams of Prozac per day for 3 months while the other 26 took an inactive placebo for the same time period.

At the beginning of the study, and in the 2nd, 4th, 6th, 8th and final week of the study, the patients completed questionnaires assessing their fibromyalgia symptoms and pain.

An improvement of 25% or more in overall symptoms was observed in 8 (32%) of the 25 women taking Prozac compared with only 4 (15%) of the women who took a placebo, the report indicates.

In addition, 56% of the Prozac takers had a 25% or better improvement in pain as measured by a standardized questionnaire compared with 15% of those who took the placebo, the investigators found.

A person is diagnosed with fibromyalgia if he or she has tenderness in at least 11 of 18 specific trigger points, including the hip, elbow, knee, the neck at the base of the skull and midway between the neck and shoulder. In the current analysis, no effect of antidepressants on pain at patients' trigger points was seen.

Arnold and colleagues point out that due to the study's short duration, the results may not be generalizable to longer time periods.

In an accompanying editorial, Dr. Patrick G. O'Malley writes that "most symptom-based studies define a greater than 50% improvement in symptoms as clinically significant. Thus, using only 25% improvement to define success may be overstating the efficacy of fluoxetine in fibromyalgia. Clearly, this is not a therapy that had a dramatic effect on outcomes in this sample."

The editorialist concludes that "it is safe to say that antidepressants, including SSRIs, are effective in treating patients who have such symptom syndromes as fibromyalgia, but many questions remain as to why, how much, which, and how long."

SSRIs, or selective serotonin reuptake inhibitors, are a class of antidepressant drugs--including Prozac--that increase levels of the brain chemical serotonin.

Eli Lilly, the pharmaceutical company that makes Prozac, funded the study.

SOURCE: The American Journal of Medicine 2002;112:191-197, 237-238.

Please Discuss This Article:   Post a Comment 

[ Be the first to comment on this article ]

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing