ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

How Can You Benefit From Vitamin B12?

Calorie restriction promotes longevity through effects on mitochondrial network

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

What Is Bitter Orange?

Black Tea Is Great for Your Gut

Drug can dramatically reduce weight of people with obesity

Tryptophan's Possible Effects for Your Health

 
Print Page
Email Article

New method of turning off viruses may help control HIV infection, says Jefferson scientist

  [ 32 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 3, 2002


A natural method of disarming some types of viruses may enable scientists to someday treat infections with HIV, the AIDS virus, according to a virologist at Jefferson Medical College.

Taking the lead from the common fruit fly, yeast and worms, scientists have recently shown that it may be possible to use small pieces of genetic material called short interfering RNAs (siRNAs) to inhibit HIV from making more copies of itself.

The process, called RNA interference (RNAi), was first discovered in 1998. It is so novel, says virologist Roger J. Pomerantz, M.D., professor of medicine, biochemistry and molecular pharmacology and chief of the division of infectious diseases at Jefferson Medical College of Thomas Jefferson University in Philadelphia, that scientists only now are beginning to understand its potential to treat disease. "What's so exciting for HIV therapy is that it may be a potent way of specifically inhibiting the virus," says Dr. Pomerantz, whose commentary accompanies a paper on the topic in the July 2002 issue of Nature Medicine.

"Does it [RNAi] work in mammals? That would be the Holy Grail," says Dr. Pomerantz, who is also director of the Center for Human Virology at Jefferson Medical College. "Researchers are showing it in mouse cells and now a team has demonstrated it in human cells."

So-called "gene silencing" isn't new. According to Dr. Pomerantz, scientists have known for several decades that organisms can and do shut off the expression of certain genes. But, he says, no one until recently has been able to show this was occurring during the gene replication process. Scientists showed that they could stop a gene from replicating by degrading the gene's RNA and making its protein product.

Researchers learned several years ago that certain organisms - some worms, fruit flies, yeast and even plants - use a type of RNA called double-stranded RNA (dsRNA) to shut off genes. Dr. Pomerantz explains that dsRNA is cut up by an enzyme, "Dicer," into smaller siRNAs, which in turn attach to RNA being made by the cell, rendering it useless.

Scientists showed recently that RNAi could work in mammalian cells. In the current issue of Nature Medicine, researchers at Massachusetts Institute of Technology reported a series of experiments demonstrating how siRNAs might be used to fight HIV, which is an RNA virus. They used siRNAs in two ways. They showed they could silence both cellular genes necessary for HIV infection and also use siRNAs to quiet an HIV gene itself.

Dr. Pomerantz points out that the MIT report is an important step in understanding the process. "This [MIT work] is a proof of concept," he says. "The MIT team showed RNAi could work for HIV.

"Now, we need to figure out how it works and how long it lasts," he says. "Does it spread between cells? How robust is it in inhibiting HIV? Can we use it against virtually any RNA virus?" RNAi may also be useful against cancer-causing oncogenes, he adds.

"I think it [this technology] is going to explode," Dr. Pomerantz says. "It has the potential to lead to novel forms of drugs for many diseases, but there's a lot of science to be done first to catch up to these observations."

Contact: Steve Benowitz or Phyllis Fisher, 215-955-6300. After Hours: 215-955-6060



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
The Genetic Mutation That May Compromise Your Health - And What to Do About It The Genetic Mutation That May Compromise Your Health - And What to Do About It
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map