ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

Proton pump inhibitors decrease diversity in gut microbiome, increase risk for complications

 
Print Page
Email Article

New method of turning off viruses may help control HIV infection, says Jefferson scientist

  [ 32 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 3, 2002




A natural method of disarming some types of viruses may enable scientists to someday treat infections with HIV, the AIDS virus, according to a virologist at Jefferson Medical College.

Taking the lead from the common fruit fly, yeast and worms, scientists have recently shown that it may be possible to use small pieces of genetic material called short interfering RNAs (siRNAs) to inhibit HIV from making more copies of itself.

The process, called RNA interference (RNAi), was first discovered in 1998. It is so novel, says virologist Roger J. Pomerantz, M.D., professor of medicine, biochemistry and molecular pharmacology and chief of the division of infectious diseases at Jefferson Medical College of Thomas Jefferson University in Philadelphia, that scientists only now are beginning to understand its potential to treat disease. "What's so exciting for HIV therapy is that it may be a potent way of specifically inhibiting the virus," says Dr. Pomerantz, whose commentary accompanies a paper on the topic in the July 2002 issue of Nature Medicine.

"Does it [RNAi] work in mammals? That would be the Holy Grail," says Dr. Pomerantz, who is also director of the Center for Human Virology at Jefferson Medical College. "Researchers are showing it in mouse cells and now a team has demonstrated it in human cells."

So-called "gene silencing" isn't new. According to Dr. Pomerantz, scientists have known for several decades that organisms can and do shut off the expression of certain genes. But, he says, no one until recently has been able to show this was occurring during the gene replication process. Scientists showed that they could stop a gene from replicating by degrading the gene's RNA and making its protein product.

Researchers learned several years ago that certain organisms - some worms, fruit flies, yeast and even plants - use a type of RNA called double-stranded RNA (dsRNA) to shut off genes. Dr. Pomerantz explains that dsRNA is cut up by an enzyme, "Dicer," into smaller siRNAs, which in turn attach to RNA being made by the cell, rendering it useless.

Scientists showed recently that RNAi could work in mammalian cells. In the current issue of Nature Medicine, researchers at Massachusetts Institute of Technology reported a series of experiments demonstrating how siRNAs might be used to fight HIV, which is an RNA virus. They used siRNAs in two ways. They showed they could silence both cellular genes necessary for HIV infection and also use siRNAs to quiet an HIV gene itself.

Dr. Pomerantz points out that the MIT report is an important step in understanding the process. "This [MIT work] is a proof of concept," he says. "The MIT team showed RNAi could work for HIV.

"Now, we need to figure out how it works and how long it lasts," he says. "Does it spread between cells? How robust is it in inhibiting HIV? Can we use it against virtually any RNA virus?" RNAi may also be useful against cancer-causing oncogenes, he adds.

"I think it [this technology] is going to explode," Dr. Pomerantz says. "It has the potential to lead to novel forms of drugs for many diseases, but there's a lot of science to be done first to catch up to these observations."


Contact: Steve Benowitz or Phyllis Fisher, 215-955-6300. After Hours: 215-955-6060


Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing