ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Option For Chronic Fatigue Syndrome

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

Stop Bacteria With Nature's Antibiotics

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

New Test Shows Promise in Identifying New Drugs to Treat Lyme Disease

Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

Strengthen Cell Function with Energy-Boosting Niagen

Dietary Flavanols Reverse Age-Related Memory Decline

Vitamin D deficiency increases poor brain function after cardiac arrest by sevenfold

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

 
Print Page
Email Article

New method of turning off viruses may help control HIV infection, says Jefferson scientist

  [ 32 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 3, 2002




A natural method of disarming some types of viruses may enable scientists to someday treat infections with HIV, the AIDS virus, according to a virologist at Jefferson Medical College.

Taking the lead from the common fruit fly, yeast and worms, scientists have recently shown that it may be possible to use small pieces of genetic material called short interfering RNAs (siRNAs) to inhibit HIV from making more copies of itself.

The process, called RNA interference (RNAi), was first discovered in 1998. It is so novel, says virologist Roger J. Pomerantz, M.D., professor of medicine, biochemistry and molecular pharmacology and chief of the division of infectious diseases at Jefferson Medical College of Thomas Jefferson University in Philadelphia, that scientists only now are beginning to understand its potential to treat disease. "What's so exciting for HIV therapy is that it may be a potent way of specifically inhibiting the virus," says Dr. Pomerantz, whose commentary accompanies a paper on the topic in the July 2002 issue of Nature Medicine.

"Does it [RNAi] work in mammals? That would be the Holy Grail," says Dr. Pomerantz, who is also director of the Center for Human Virology at Jefferson Medical College. "Researchers are showing it in mouse cells and now a team has demonstrated it in human cells."

So-called "gene silencing" isn't new. According to Dr. Pomerantz, scientists have known for several decades that organisms can and do shut off the expression of certain genes. But, he says, no one until recently has been able to show this was occurring during the gene replication process. Scientists showed that they could stop a gene from replicating by degrading the gene's RNA and making its protein product.

Researchers learned several years ago that certain organisms - some worms, fruit flies, yeast and even plants - use a type of RNA called double-stranded RNA (dsRNA) to shut off genes. Dr. Pomerantz explains that dsRNA is cut up by an enzyme, "Dicer," into smaller siRNAs, which in turn attach to RNA being made by the cell, rendering it useless.

Scientists showed recently that RNAi could work in mammalian cells. In the current issue of Nature Medicine, researchers at Massachusetts Institute of Technology reported a series of experiments demonstrating how siRNAs might be used to fight HIV, which is an RNA virus. They used siRNAs in two ways. They showed they could silence both cellular genes necessary for HIV infection and also use siRNAs to quiet an HIV gene itself.

Dr. Pomerantz points out that the MIT report is an important step in understanding the process. "This [MIT work] is a proof of concept," he says. "The MIT team showed RNAi could work for HIV.

"Now, we need to figure out how it works and how long it lasts," he says. "Does it spread between cells? How robust is it in inhibiting HIV? Can we use it against virtually any RNA virus?" RNAi may also be useful against cancer-causing oncogenes, he adds.

"I think it [this technology] is going to explode," Dr. Pomerantz says. "It has the potential to lead to novel forms of drugs for many diseases, but there's a lot of science to be done first to catch up to these observations."


Contact: Steve Benowitz or Phyllis Fisher, 215-955-6300. After Hours: 215-955-6060


Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Black Friday Sale

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
VIDEO: Healthy Eating and Fibromyalgia VIDEO: Healthy Eating and Fibromyalgia

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing