ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

Can Pomegranates Slow Aging?

Calorie restriction promotes longevity through effects on mitochondrial network

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

How Can You Benefit From Vitamin B12?

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

What Is Bitter Orange?

Drug can dramatically reduce weight of people with obesity

 
Print Page
Email Article

Carnitine supplementation could improve cold tolerance and more

  [ 2 votes ]   [ Discuss This Article ]
By Life Extension • www.ProHealth.com • October 30, 2017


Reprinted with the kind permission of Life Extension.

October 23 2017. The September 5, 2017 issue of Cell Metabolism reported research findings from the University of Utah School of Medicine that reveal a role for carnitine in the body’s response to cold temperatures.

“Cold-induced thermogenesis is an energy-demanding process that protects endotherms against a reduction in ambient temperature,” Judith Simcox, PhD, and colleagues write. “We found that the liver undergoes a metabolic switch to provide fuel for brown fat thermogenesis by producing acylcarnitines.”

“Cold stimulates white adipocytes to release free fatty acids that activate the nuclear receptor HNF4?, which is required for acylcarnitine production in the liver and adaptive thermogenesis,” they continue. “Once in circulation, acylcarnitines are transported to brown adipose tissue, while uptake into white adipose tissue and liver is blocked.” 

Acylcarnitines are fatty acyl esters of L-carnitine that were found to increase in young mice during cold adaptation. "It was surprising to see acylcarnitines in the bloodstream," Dr Simcox remarked. "The dogma was that once cells generated them, they used them right away."

With aging comes a decline in the ability to adapt to cold exposure. In the current study, researchers found that a single dose of L-carnitine or palmitoylcarnitine improved aging-related cold sensitivity in mice. Because activating cold adaptation burns calories, improving the process be useful for more than the ability to tolerate cold environments.

"This work is putting a new face on an old character," Dr Simcox stated. "We're changing how we think about cold-induced thermogenesis."



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Can Pomegranates Slow Aging? Can Pomegranates Slow Aging?
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map