ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Magnesium: Widespread Deficiency with Deadly Consequences

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Reverse Mitochondrial Damage

Strengthening DNA to Prevent Inflammation, Heart Disease, Dementia and More

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

CoQ10: The Longevity Factor

Turmeric compound boosts regeneration of brain stem cells

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

Extending Life and Fighting Disease with Resveratrol

Is Homocysteine Making You Sick?

 
Print Page
Email Article

UK Charity Launches Major Study Into CFS/ME and Pain

  [ 7 votes ]   [ 2 Comments ]
www.ProHealth.com • March 2, 2013


~Source: The CFS Research Foundation

The CFS Research Foundation, based in Hertfordshire, England, has agreed to fund an ambitious, cutting edge study into why so many Chronic Fatigue Syndrome/ME sufferers experience heightened pain. The three-year study will be conducted by a team of UK scientists and clinicians at Bart’s and the London Medical School, Imperial College and Imanova, a centre of excellence for imaging sciences. 

Entitled “The neurophysiology of pain in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)”, the study will seek to discover the physiological and chemical abnormalities underlying pain in CFS/ME patients. A large majority of people with CFS/ME suffer from a number of painful symptoms including muscle and joint pain, headaches, sore throat and lymph node pain. Many endure chronic widespread pain which can become unbearable. An additional problem for these sufferers is that normal pain killers do little to ease their pain. 

Scientists and doctors know very little about why pain is such a problem but there is some evidence to suggest that the way the brain handles pain signals in CFS/ME patients is different from that in healthy people. There are two potential reasons: spinal sensitisation, in which non-painful sensations are felt as painful because nerves that are not specialised in detecting pain tell the spinal cord that what is being felt is hurting us, (called allodynia) while mildly painful sensations are felt as unbearable because the brain’s natural defences don’t fire and central augmentation in which the brain’s pain matrix becomes overly sensitive, reacting faster than normal to the possibility of pain which it then interprets as being more painful and unpleasant. Together these are referred to as Central Sensitisation. This condition is not specific to CFS/ME but the particular biological and biomedical mechanisms which cause it in CFS/ME sufferers is unknown. 

The research team will attack the problem on four fronts. Firstly, they will measure pain thresholds to a number of potentially painful stimuli (e.g. pressure and heat) and assess whether there is spinal cord sensitivity to pain (spinal sensitisation). Secondly, they will use cutting edge fMRI (functional Magnetic Resonance Imaging) to scan the brains of CFS/ME patients, to examine the pain matrix (pain pathways), and see how they differ from healthy controls. Thirdly, they will use two medications that block two of the brain’s pain chemical transmitters (dopamine and the opioids) in combination with fMRI to see how they are involved in the pain pathways and the response to pain. Finally, the team will see whether the differences in pain levels, central sensitisation and activity of the pain matrix are related to differences in a particular gene in CFS/ME patients. 

The research will lead to a better understanding of how the brain is involved in pain symptoms in CFS/ME patients, how certain brain chemicals and the gene involved in their metabolism, are involved and thus provide a way forward to consider more effective treatments. 

The CFS Research Foundation’s Honorary Director, Anne Faulkner said: “The Foundation maintains its belief that it is essential that the basis of CFS/ME must continue to be at the top of its agenda. We must understand the causes of the disease before we can find a cure. While our long term research continues, we decided it was time to widen our research by trying to obtain a deeper understanding of how one particular organ might be involved in causing a particularly distressing symptom endured by many people with CFS/ME – namely pain. To find therapies to relieve pain could change lives.” 

You can find out more about the CFS Research Foundation and its work by visiting its website 

 


Please Discuss This Article:   Post a Comment 

Barking up the wrong tree - again
Posted by: IanH
Mar 2, 2013
This idea that pain in ME/CFS is a sensitivity issue is far from the whole story and it ignores the important studies by Prof. Alan Light which tells us that the origin of much of the pain is immunological via a low grade inflammatory process. Some of the pain originates in muscle and other fibrous tissue which when over worked creates (yes creates) pain due to the sustained release of pro-inflammatory and pain generating and amplifying cytokines.

The sensitivity theory suggests that the sensations are normal but interpreted as pain and there is no muscle or fibrous tissue problem. This is insufficient to explain the data.

To me this study and the money allocated to it is mis-guided. However it will no doubt uncover some useful information.
Reply Reply

Look at the personnel
Posted by: 43
Mar 5, 2013
This sounds good on paper, but the CFSRF has now engaged Esther Crawley to their Research Committee, which should sound warning bells for anyone with authentic ME who doesn't think their disease can be treated using mind manipulation such as LP.

http://cfsrf.org.uk/index.php?option=com_content&view=article&id=51:research-committee&catid=35:who-is-involved&Itemid=59
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing