Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Netwo...

International Lyme and Associated Diseases Society Hosts Its Annual Scientific Conference in Ft. Lau...

Lyme Camp- A Unique Event for People with Lyme Disease

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Acupuncture reduces hot flashes in breast cancer survivors

Top 7 Nutrient-Dense Foods That Make Calorie Counting Obsolete

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

SURVEY: Has Your Illness Affected What You Eat?

DePaul Study Recruiting Participants

VIDEO: Dr. Horowitz Discusses Lyme Disease and Chronic Illness

Print Page
Email Article

Some Cases of Fibromyalgia May Actually Be Small-Fiber Polyneuropathy

  [ 32 votes ]   [ 3 Comments ] • June 16, 2013

Editor's comment: Small-fiber polyneuropathy involves body-wide damage to the small unmyelinated nerve fibers.  (Unmyelinated means the nerve fibers do not have a myelin sheath – the fatty substance that covers and protect nerves.)

Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia.


Fibromyalgia is a common, disabling, syndrome that includes chronic widespread pain plus other diverse symptoms. No specific objective abnormalities have been identified, precluding definitive testing, disease-modifying treatments, and identification of causes.

In contrast, small-fiber polyneuropathy (SFPN), despite causing similar symptoms, is definitionally a disease caused by dysfunction and degeneration of peripheral small-fiber neurons. SFPN has established etiologies, some diagnosable and definitively treatable, e.g., diabetes.

To evaluate the hypothesis that some patients labeled with "fibromyalgia" have unrecognized SFPN causing their illness symptoms, we analyzed SFPN-associated symptoms, signs, and pathological and physiological markers in 27 fibromyalgia patients and 30 matched normal controls. Fibromyalgia subjects had to satisfy American College of Rheumatology criteria plus document actual fibromyalgia diagnoses.

Study instruments comprised the Michigan Neuropathy Screening Instrument (MNSI), the Utah Early Neuropathy Scale (UENS), distal-leg neurodiagnostic skin biopsies, plus autonomic-function testing (AFT).

  • 41% of skin biopsies from fibromyalgia subjects vs. 3% of biopsies from control subjects were diagnostic for SFPN, and

  • MNSI and UENS scores were higher among fibromyalgia than control subjects (all P ? 0.001).

  • Abnormal AFTs were equally prevalent suggesting that fibromyalgia-associated SFPN is primarily somatic [of or relating to the body].

  • Blood tests from all 13 fibromyalgia subjects with SFPN-diagnostic skin biopsies provided insights into etiologies.

  • All glucose tolerance tests were normal, but eight subjects had dysimmune markers, 2 had hepatitis C serologies, and one family had apparent genetic causality.

These findings suggest that some pain patients labeled with "fibromyalgia" have unrecognized small-fiber polyneuropathy, a distinct disease that can be objectively tested for and sometimes definitively treated.

Source: Pain, June 5, 2013. By Anne Louise  Oaklander, Zeva Daniela  Herzog, Heather  Downs and Max M.  Klein. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114; Department of Pathology (Neuropathology), Massachusetts General Hospital, Boston, Massachusetts, 02114.

Please Discuss This Article:   Post a Comment 

More evidence that FM is a syndrome with underlying disease
Posted by: IanH
Jun 16, 2013
Here we have 41% of this sample have sfpn. We know that around 42% of people with ME/CFS meet the criteria for FM.

Some earlier studies have shown that a significant % of people diagnosed with FM have spinal stenosis, mainly cervical myelopathy but also lumbar and even some with thoracic stenosis and vertebral compression fracture from motor accidents. Dr Dan Heffez and Alan Shephard showed this many years ago.

We are now getting close to showing that FM is a symptomatic syndrome caused by an underlying neural pathology (which sometimes has its origin in the immune interface) that needs identifying and treating.

Where is the so-called primary fibromyalgia? It does not exist!
Reply Reply

Now with link :-)
Posted by: Helpfuljosh
Jun 11, 2014


Dear IanH
Posted by: Helpfuljosh
Jun 11, 2014
You might find this article interesting. It is about the effects of cannabis on fybromyalgia patients. I found it quite interesting.
Cannabis-Fibromyalgia Sensi Blog


Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing