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Cymbalta Warning: Discontinuing May Result in Severe Withdrawal Symptoms

  [ 197 votes ]   [ 25 Comments ]
By Karen Lee Richards • www.ProHealth.com • March 10, 2014


Cymbalta Warning: Discontinuing May Result in Severe Withdrawal Symptoms
In 2008, Cymbalta became the second drug to receive FDA approval for the treatment of fibromyalgia. It was classified as a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant. At the time, the FM community was excited to have another medication available that would hopefully reduce pain for at least some FM patients. Little did we suspect the misery that could result when those patients wanted to stop taking Cymbalta.

The medical community has long known that abruptly discontinuing any antidepressant can result in Antidepressant Withdrawal Syndrome. That's why patients are (or should be) strongly urged not to suddenly quit taking an antidepressant but to talk with their doctor about gradually tapering off the medication.

Cymbalta Discontinuation Syndrome

However, neither physicians nor patients expected the severity of withdrawal from Cymbalta. In fact, it's bad enough to warrant its own diagnosis – Cymbalta Discontinuation Syndrome. An FDA advisory committee report about Cymbalta Discontinuation Syndrome states, “Much anecdotal evidence has accumulated documenting the injury, distress and life management impacts caused by discontinuation of Cymbalta. The effects of discontinuation can be severe and extend for weeks or even months.”

As you read through patient descriptions of their Cymbalta withdrawal experiences, it's not uncommon to see terms like “horrific,” “a nightmare,” and “going through hell.” Some of the withdrawal symptoms described include:

“Brain zaps”
(electric shock sensations)
Extreme mood swings
(“irritability that quickly turns to rage”)
Suicidal thoughts Paranoia
Dizziness Confusion
Nausea and Vomiting Limb pain
Headache Fatigue
Nightmares Insomnia
Diarrhea Anxiety
Excessive sweating Agitation
Involuntary crying or laughing Hypomania
Tinnitus Seizures

The Discontinuation Dilemma

When it comes to discontinuing Cymbalta, the prescribing information says, “A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Subsequently, the physician may continue decreasing the dose but at a more gradual rate.”

While gradually reducing the dose sounds like a reasonable approach, there is one very big problem. Cymbalta is only available in three dosages: 20 mg., 30 mg. and 60 mg. To complicate things even further, Cymbalta is a capsule, not a tablet that can be cut in half. Adding insult to injury, patients are warned, “Cymbalta...should not be chewed or crushed, nor should the capsule be opened and its contents sprinkled on food or mixed with liquids.” So although Cymbalta manufacturer, Eli-Lilly, recommends gradually reducing the dose, there is virtually no way to actually do that.

What Can You Do?

If you're currently taking Cymbalta and want to stop, talk with your doctor about developing a discontinuation plan. Make sure your doctor is aware of how severe Cymbalta Discontinuation Syndrome can be and discuss possible options for treating the various symptoms that you may experience. Some doctors have tried switching patients to a different antidepressant that is easier to taper off of and then treating other symptoms with appropriate medications (like antiemetics, antihistamines, etc.) through the withdrawal process.

If you are contemplating whether or not to take Cymbalta, be aware of what you're getting yourself into. Trying to get off of the drug may leave you feeling far worse than the fibromyalgia symptoms you're trying to relieve. Thoroughly discuss the pros and cons with your doctor before making a decision.



Please Discuss This Article:   Post a Comment 

Exact same problem with Pristiq, when are drug companies going to be held accountable?
Posted by: aryiella
Mar 11, 2014
I am on Pristiq 50mg once a day and have been for a few years. I take it for depression and fibro. It is not helping my depression anymore but there is no way to get off of it! And so I am stuck on this stuff and cannot try any other meds until I am off this one! There is no smaller dose than 50mg and the tablet is time-released and cannot be cut or it will not release the medicine in the proper way. I would prefer to not switch to Effexor as a replacement due to the additional side effects I had when on that previously. Pfizer is extremely irresponsible for putting a drug out like this that CANNOT be properly tapered without EXTREME discontinuation symptoms. I have been contacting attorneys, but nobody is interested.
Reply Reply

 
Phone the FDA 1-800-FDA-1088 Mon–Fri between 8:00 a.m. and 4:30 p.m. EST
Posted by: Altostrata
Mar 12, 2014
Also make a complaint to Pfizer, Pristiq's manufacturer: (800) 438-1985 in the US.

Rxisk.org is also collecting complaints about Pristiq.

If you think your doctor has been remiss, file a complaint with your state medical board if you're in the US.

 


Please heed this article
Posted by: tbrhslp
Mar 11, 2014
I can attest to SEVERE withdrawl symptoms with Cymbalta. Without going into detail, please know that one should absolutely consult their physician before discontinuing and be prepared to have family or friends able and willing to help keep an eye on you during the discontinuation.
Reply Reply

You can open the Cymbalta capsules and count out beads
Posted by: Altostrata
Mar 12, 2014
You can indeed open the Cymbalta capsules and count out the beads, but you cannot dissolve Cymbalta in anything.

The gelatin capsule doesn't do anything. The coating on each bead protects it from being dissolved in your stomach. This destroys the drug. Cymbalta is absorbed further down in your intestines.

Many, many patients have found this is the way to taper off Cymbalta. Some people are so sensitive to dosage reductions, they can reduce only a bead at a time, by week or even by month.

You can search the Web and find many, many reports of severe Cymbalta withdrawal syndrome, and many people tapering by the bead-counting method because it's the only way to go off gradually enough.
Reply Reply

hell
Posted by: catz902001
Mar 12, 2014
I was on 60mg twice a day for 7 yrs along with blood pressure meds and sleeping pills. One day I just decided that I was sick of taking all the meds and I stopped cold turkey. It was hell for a few weeks and my husband and family really suffered with me. But I did it and by adding a few supplements I did really good for about a year. But we had a death in the family and all the stress set off a horrible flare. Now I am back on all of them again. I have been in a bad flare for 2 months but as soon as it breaks, I am going to try again
Reply Reply

Same story, different med
Posted by: Juloo
Mar 13, 2014
I'm in the process of going from Effexor (venlafaxine) to Welbutrin (bupropion). While ramping up with the new med, the doctor had me slowly reducing the Effexor from 150 to 73 to 37.5, then opening the capsules and using half the grains, a quarter, etc.

After a couple of weeks of the last step, I stopped all Effexor. I was relieved to have weathered the switch so smoothly.

Then about a week later, 'discontinuation symptoms' like those listed above set in. Within a few days, I was very emotionally changeable (so not me) running between anger and tears daily. And the brain zaps! It was no different than the weekend I was traveling and had forgotten to bring my meds...from 150 to 0. Awful! Except that this time the jump had been from about 15 mg to 0 - and with support from another med!

Suspecting this might be the case, I counted out a few grains - I figure altogether under 1/10 of the 37.7 capsule, so under 4 mg - and after fits and starts, take this daily until I can see my doctor. I may need to be in this holding pattern a little longer and taper grain by grain. Even several months!

After reading this article, I did more research online and found a study that suggested those tapering off Cymbalta are about 3 times more likely to experience this sitation than Effexor users. My most sincere sympathies to all here undergoing this transition with this reaction. I wouldn't wish it on my worst enemy.

Effexor was a god-send
Reply Reply

 
Hmmm
Posted by: Juloo
Mar 13, 2014
I don't know why that 'Effexor was a god-send was dangling there...although it was true when I began and for the 7 years I took it until it gradually stopped working. But it isn't giving up the ghost quietly!

Edit...150 to -75- to...

I'm posting from an iPad, so entering text is sometomes hit and miss...

 


Effexor Withdrawal
Posted by: mrswoody
Mar 16, 2014
I took Effexor for years too. I started on it right after it came out when they were still figuring out the dosage. I was on 450mg a day for 4 years when I decided I wanted to stop it. I tried telling my doctors that I had "electric head"(my name for the brain zaps)and horrible anxiety, nausea, etc. but they just didn't believe me. My doctor said to me "you are the only person I know who could get addicted to an antidepressant". After the DSM finally listed the withdrawal symptoms and I showed it to my doc, he started tapering me off. It didn't come in a capsule then so I had to cut up the pills once I got to the lowest dose pill which was 37.5. I got all the way down to a little crumb and I just could not get completely off. It took a full year of reducing it by one a week, then every 5 days, 4 days, etc. before I was finally able to get off it. That was 10 years ago and I still have "electric head".

I recently went on Cymbalta for depression and fibromyalgia but after reading this I am not taking it anymore.
Reply Reply

Lily website
Posted by: Zachary1018
Apr 4, 2014
So I go to the Lily website because I could swear they tout that it isn't a narcotic. If you go to the products page you can click on every product. Except Cymbalta. Try it and tell me whether or not I'm crazy. If it is blocked out, then why?
Reply Reply

 
Reply to Zachary1018
Posted by: katkar
Apr 4, 2014
You're right. I couldn't click on Cymbalta either. You can still click on the Prescribing Information and the Patient Information but not on the product name. I"m not sure what that's about.

I can tell you, however, that Cymbalta is not a narcotic; it's an antidepressant. Most of us tend to think of withdrawal as only happening when someone stops taking narcotics (opioids). But there are a number of other drugs that result in withdrawal symptoms if you stop taking them abruptly. That's true of most antidepressants. Judging from what many patients and some doctors have said, though, SNRI antidepressants in general and Cymbalta in particular seem to have more severe withdrawal symptoms than some other types of antidepressants. So it's important to taper off of those medications as gradually as possible. – Karen

 


Cymbalta Withdrawal
Posted by: JanisMarie
Apr 9, 2014
I was on Cymbalta for fibro for 18 months, and it gradually became ineffective. It took MONTHS to get off, which I did very gradually. The brain zaps drove me crazy and frightened me. Then I developed Periphial,neuropathy, since my B12 was extremely low. I'm missing the intrinsic factor in my gut which breaks down the B12 from food. Causes pernicious anemia, which used to be fatal, until B12 shots could be given.
Well, the neuropathy was absolutely horrible...made fibro seem like a walk in the park! Of course, guess what relieved the neuropathy? Yep! Cymbalta. It has now been over 18 months and once again losing it's effectiveness. Now I'm going to go through the misery of withdrawal all over again.
I used to be such a healthy person:(
Reply Reply

 
Vitamin B 12 and other things Cymbalta
Posted by: connielhill
Sep 25, 2014
Hey, I don't have B12 either. Every time I get blood work they say, "no B12 and dehydrated". I drink tons of water all day and night. Not sure what any of this means but there it is. I guess I wonder what anyone can do diet-wise to help with whatever Cymbalta is suppose to cure!? I am now gluten free and ready to try anything natural to feel better damnit!

 


Oh my gosh
Posted by: Drifter110
Jul 22, 2014
I went to my rheumatologist today to discuss the next steps as in the past 4 months I have weaned off of 100mg Pristiq and was switched to 60 of Cymbalta for my fibromyalgia. After two weeks on Cymbalta I did not like the side effects and she had me wean off by taking every other day then every two days then three days then none. In speaking with her of the terrible side effects, suicidal thoughts, extreme anger and stomach issues etc she told me I needed a psychologist as I have sever mental issues and NEVER had she EVER heard anyone have these symptoms and that I was probably Bi-Polar and should switch from my shitty therapist to a psychologist immediately. She suggested I find a psychologist immediately as must have a sever imbalance in my brain that would cause these side effects and there was no way these drugs caused me to feel that way.
Needless to say, I am not going back there. So happy I found this page as I know I am not bi-polar or insane and think my doctor was way out of line. Thoughts?
Reply Reply

Cymbalta Withdrawal
Posted by: FMeditor
Jul 30, 2014
Drifter110 – Although Cymbalta has been on the market for 10 years, I'm finding many doctors are just beginning to learn that it can have such severe withdrawal symptoms. However, that is no excuse for the way your doctor treated you. All she would have had to do is Google 'Cymbalta withdrawal' to discover your experience is not that unusual. In fact, one of the top links that shows up is a document issued by the FDA because of all the complaints they received. They even gave what you experienced an official name – Cymbalta Discontinuation Syndrome. You can read and download a copy of the FDA document at http://www.fda.gov/downloads/Advisor.../UCM172866.pdf I hope you're able to find a more understanding doctor.
Reply Reply

What Physicians don't tell you when they prescribe those dangerous drugs.
Posted by: judimld
Aug 8, 2014
Any drug that will interfere with serotonin or norepinephrine activity will cause your body to stop making them naturally. Therefore you will be completely dependent on the drug to regulate those two important elements. Once you stop taking the drug, of course, your body will take awhile to secrete those elements again and you will experience these terrible drug withdrawal symptoms. This is when the so called medical experts, who have created this synthetic chemical imbalance in your body will go a step further and diagnose you with the second most serious psychiatric disorder next to Schizophrenia, BIPOLAR Disorder.. and then God help you to get out of this psychiatric trap and get living on your own energy again. These drugs are dangerous and have ruined many people's lives. I managed to survive this entrapment almost twenty years ago and have written my story in a book called Judging Judi.
Reply Reply

Cymbalta Discontinuation - Misdiagnosed as Bipolar
Posted by: hermeneutic123
Sep 6, 2014
Judy,

You are absolutely correct. I had severe irritability and suicidal thoughts every time I tried to taper off of Cymbalta and with no history of these symptoms in 35 years my doctor prescribed me Lithium for being bipolar. No one ever informed me about this including my psychiatrist or that this was even a possibility. My side effects were so pronounced when trying to stop the drug that in 2012 the State of South Carolina adjudicated me a mental defective and they ignored the fact that this syndrome existed. Prior to this I was a successful academic and corporate executive with no history of mental illness. I was prescribed Cymbalta for depression I was experiencing while going through a nasty divorce. Though I was discharged by my psychiatrist a year ago and only have the diagnosis of ADD I am now labeled and slandered all over the internet. I continue to excel at work but lose one management position after another when my name is Googled. I lost my home, cars, and filed bankruptcy all because Eli Lilly hid the effects of coming off this drug.

Tony
Reply Reply

Answer to withdrawing from Pristiq and effexor
Posted by: lwspeer
Sep 12, 2014
I took pristiq and had to start taking effexor for insurances purposes. I took the extended release for abut two years and soon realized I must get off of this drug. I was losing my hair, having wieght gain, had terrible headaches, asthma symptoms as well as sever dizziness from which I had to go to bed. I went to a new doctor and she tapered me off by adding 1 Prozac plus the 1 Effexor I was taking daily. AT the end of 5 days I was to stop Effexor, and I am doing fine. Neither Pristiq and Effexor helped my depression and the side effects were terrible. When I stopped it I lost 9 pounds in 2 weeks, and everyone in my family has noticed a change in me. I no longer have these dangerous symptoms and feel a great deal better.
Reply Reply

Brain zaps partial seizures
Posted by: eguillot
Sep 22, 2014
I have been on Cymbalta for Fibromyalgia for several years now. I also have epilepsy, and I can tell you that the "brain zaps" are EXACTLY the same feeling that I get right before I have a grand mal seizure. My neurologist calls them partial seizures. So probably those "brain zaps" that everyone is getting from withdrawal are actually partial seizures.
Reply Reply

Cymbalta Withdrawal Lawsuits Now Being Filed
Posted by: roberthilley
Sep 24, 2014
The manufacturer of Cymbalta is facing a number of lawsuits from people who experienced withdrawal symptoms after stopping Cymbalta (duloxetine).

The label states that withdrawal occurs in at least 1% of patients, but studies have found that at least 50% of patients experience withdrawal and 10% of the cases are severe.

If you or somebody you know has taken Cymbalta and suffered from severe withdrawl symptoms, you may be entitled to financial compensation. You can learn more by visiting http://www.schmidtlaw.com/cymbalta-withdrawal-lawsuit/ or you can contact the law firm for a free case review by dialing (866) 920-0753.
Reply Reply

 
Lawsuits against cures, hmmm
Posted by: connielhill
Sep 25, 2014
I don't understand. If someone needs medicine for an affliction and goes to a doctor and gets medication who is to blame? Are you saying we should have been given a disclaimer to sign? Come on, I am in the throws of Cymbalta withdrawal and if I had to point a finger at who put me here...I couldn't. I mean if there is one sure thing to know about any drug is IT'S A DRUG. Some provide real, life saving results and even those can have sketchy side effects. It's about balance and choice, our own choice, no? If we keep suing the drug companies we will NEVER get a cure for cancer! Now I'm not saying these guys are always good guys but if you have ever suffered a disease so horrible that you would take snake venom to feel better you would know that worrying about the backside is not even in the realm of "what if's" because if tomorrow and for a year or 2 your life would include joy, laughter and health you might just take that snake venom, it's up to you.

 


Who knew? Cymbalta withdrawal ongoing.
Posted by: connielhill
Sep 25, 2014

I am a 62 yr old female and this is my experience:
I see others had been on Effexor as was I. I guess it stopped working? I can't quite say but I never had problems with Effexor. New Doctor switched me to Cymbalta a few years ago. I too was on Welbutrin with the Cymbalta. I also, since I have no thyroid, that came out earlier this year with a cancer scare, take Synthroid and Caduet for high blood pressure AND cholesterol. Add to these Adderal for ADHD. Absurd, too much!

Then I developed a disgusting skin thing, they called it nummular eczema/dermatitis. So I was put on Dapsone AND Cyclosporine. Insanity! So all by myself, in an effort to heal my skin, I decided to go gluten free and to get off some of these meds. I was convinced one of them was causing my skin issue which by the way, is the worst itch I have ever, ever, experienced, absolutely no relief, and so repulsive...you have no idea, all over my legs, arms, hands, looks like boils, so I have that going for me!:( Yuk.

For about a week all seemed to be going fine as I got off Welbutrin and reduced Adderal and Cymbalta. I guess they hang out in your body for a good long while because the poop finally hit the fan a few days ago and I was sure I had MS! Nausea, weakness, aches in muscles, esp. legs and glutes. Couldn't walk the dog. Couldn't feed the dog w/o barfing. Sweating, shaking, major brain fog, words escaped me every time I tried to make sense, sounded like an idiot. I was also manic! Crazy talk happened and I was like OMG what did I just say? Shut up! Shut up! I own a vintage furniture store and also a design biz and I can't believe I have gotten this far w/o making a complete fool of myself. It has been about 2 weeks and as I was driving home today from meeting with a design client I said aloud, "here come the tears" because it was 4 PM and they always come at that time. Got home and immediately called my long time family doctor, a female, who has always helped me get right with such kindness and compassion. It was after hours but I got her via her service and she took charge, called in RX for my nausea and instructed me to get into her office in the AM with all my meds and we would figure it out. I feel hopeful. Just bracing for the dreams...
Reply Reply

Cymbalta Withdrawal Symptons
Posted by: kattails
Sep 25, 2014
I stopped my Cymbalta (90mg daily) about 2 months ago cold turkey and I still have excessive sweating. Does anyone know how long this will last. Thank you
Reply Reply

Cymbalta...what if our brain changes are permanent?
Posted by: connielhill
Sep 28, 2014

I am in week 2 1/2 of withdrawal. I have been reading so many blogs I can't keep them straight, and my w/d ain't helpin'! But has anyone considered the possibility that some of our neuropathic issues may remain forever? What if our brains are permanently scarred in some way? How will we ever know except to keep talking? I have seen some absurd entries in some blogs like the woman who wrote in (...oh!...there went a brain zap...) and said she quick cold turkey without symptoms. I don't believe her. For one, I don't have time to waste, who does? I run a business, own a home, have children, dogs, you get the picture, I am just like most of you guys writing in. Would I even think to bother to research, find and write in a blog on Cymbalta withdrawal if I had no issues? No, no I would not, so I don't get the point of some of these folks mudding up the waters. Maybe they work for Lilly, who knows. I believe via my reading and personal exp. that everybody is going to have some kind of symptoms withdrawing from this drug, period. My point is, to those of us who are writing for help and TO HELP let's keep going until the fat lady sings; when we find out if any of us are permanently scarred by Cymbalta and I guess, together, we will figure out what to do then.
PS: I don't think the term "brain zap" is a good description of what is happening in my head but it's there whatever it is, a quick ZOOOOM! and gone. Any thoughts?
Reply Reply

Suicide
Posted by: GratefulDoctor
Sep 29, 2014
I had a friend, an MSW clinical psychotherapist, who seemed the picture of emotional balance and good sense. I had not seen her in a long time, but had heard that she'd found relief from her fibromyalgia by taking Cymbalta. She posted on her website that she'd been enjoying her dog and looking forward to visiting friends in another city. Two days later she was dead at 58 years of age. I heard that it was a suicide. I do not know if she'd stopped her Cymbalta. The possibility that the medication contributed to her death haunts me.
Reply Reply

Cymbalta Withdrawal Help and Support Group
Posted by: roberthilley
Oct 1, 2014
If you are looking for a support group to assist you in coping with the withdrawal symptoms associated with the discontinued use of Cymbalta, you should check out: http://www.cymbaltawithdrawal.com
Reply Reply


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