ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Tricyclic and Tetracyclic Antidepressants Appear To Reduce Symptoms Of Chronic Low Back Pain

  [ 604 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 11, 2003


A DGReview of :"Systematic review of antidepressants in the treatment of chronic low back pain"
Spine

12/11/2003
By Jill Taylor


Antidepressants that inhibit norepinephrine reuptake (tricyclics and tetracyclics) may be mildly to moderately effective in reducing chronic low back pain, according to a new study.

Tricyclic antidepressants have been demonstrated to decrease pain associated with diabetic neuropathy, postherpetic neuralgia, as well as provide benefit in cases of fibromyalgia, migraines, and idiopathic pain.

Additionally, antidepressants are sometimes prescribed for analgesic purposes in patients with back pain. However, previous reviews have reached conflicting conclusions regarding the efficacy of antidepressants for treatment of back pain.

To assess efficacy of antidepressants for the treatment back pain and determine whether outcomes vary between antidepressant classes, Thomas O. Staiger, MD, and colleagues of the University of Washington, Seattle, United States performed a systematic literature review of randomised, placebo-controlled trials of oral antidepressive agents in patients with back pain.

Studies were identified through internet search of MEDLINE, PsycINFO, and the Cochrane Controlled Trials Registry. Independent reviewers extracted data, and assessed studies using a 22-point methodologic quality assessment scale based on the 19-point criteria list developed by the Cochrane Collaboration Back Review Group.

The reviewers identified 22 trials of antidepressants for the treatment of back pain, of which 7 studies of chronic low back pain met inclusion criteria. No adequate studies on the use of antidepressants for acute back pain were found.

Among studies using antidepressants that inhibit norepinephrine reuptake (tricyclic or tetracyclic antidepressants), 4 of 5 found significant improvement in at least 1 relevant outcome measure. Furthermore, evidence suggests that the effect of these antidepressants in chronic low back pain is independent of patient depression status.

Conversely, no analgesic benefit was observed in studies of antidepressants that do not inhibit norepinephrine reuptake (paroxetine and trazodone).

The impact of tricyclic medications on functional status in patients with low back pain was unclear. Among 4 studies of tricyclic antidepressants that included a functional measure, 1 found significant improvement, 1 found borderline significant improvements, and 2 found no significant improvement.

"More research could better-define the benefits and risks of antidepressants in the treatment of patients with chronic low back pain and whether antidepressants can improve the functional status of these patients," conclude the researchers.


Spine 2003 Nov 15;28:22:2540-5. "Systematic review of antidepressants in the treatment of chronic low back pain"



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map