ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Basic Aromatherapy to Help Balance and Calm

Tea drinkers have lower glaucoma risk

Wonderful White Tea: A Drink Fit for an Emperor

The Long-Term Benefits of Drinking Oolong Tea

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Acid Reflux May Respond Better to Foods Than Prescribed Pills

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

 
Print Page
Email Article

Probiotics News: Bacterial DNA Reduces Inflammation in Mice

  [ 52 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 4, 2004


National Institute of Allergy and Infectious Diseases (NIAID) http://www.niaid.nih.gov/default.htm NA from inactivated "probiotic" bacteria triggers a specific anti-inflammation immune response in mice with experimental colitis, researchers supported by the NIH's National Institute of Allergy and Infectious Diseases(NIAID) have discovered. Led by Eyal Raz, M.D., of the University of California, San Diego (UCSD), the investigators provide a possible explanation for the observed benefits of consuming probiotics, supplements from bacteria and other microbes, regarded by some as helpful in maintaining or restoring intestinal health. Knowing how probiotics work could give scientists a way to identify and select which probiotic bacteria might be effective against such human ailments as inflammatory bowel disease (IBD). Probiotics have shown promise for treating such IBDs as Crohn's disease and ulcerative colitis, both of which cause periodic intestinal inflammation. But scientists have had many theories of how these mixtures of "good" bacteria work, notes Marshall Plaut, M.D., of NIAID's Division of Allergy, Immunology and Transplantation. Plausible theories suggested that proliferation of the living bacteria either generated helpful metabolic products or crowded out "bad" intestinal bugs. Prior to this study, the general thinking about probiotics, which include bacteria like those found in yogurt, has been that they mediate their effects through some kind of non-specific action, adds Dr. Plaut. Dr. Raz and his colleagues, whose work is published in the February 2004 issue of the journal "Gastroenterology", irradiated a commercially available probiotic preparation, halting bacterial proliferation, but preserving its DNA. When given to mice, the irradiated probiotics performed as well as live bacteria in reducing inflammation. They also found that purified probiotic bacterial DNA alone similarly reduces inflammation in mice with experimentally induced colitis. The researchers also showed that probiotic DNA acts in a specific way by activating a defined element within the innate immune system. In animals, including humans, components of the innate immune system play complementary roles in initiating, then halting, inflammation. Improperly regulated inflammation is one symptom of IBDs. An innate immune system protein called TLR9 is a pivotal player in the chemical signaling chain that slows inflammation. In a series of experiments, the UCSD team showed that probiotic DNA exerts its effects through TLR9. Indeed, mice without the gene for TLR9 protein cannot benefit from probiotics, either living or irradiated, or from probiotic DNA. Taken together, insights into mechanisms of probiotic activity open new possibilities for probiotic therapies. For example, say some researchers, purified probiotic DNA or irradiated probiotics may be safer than viable preparations, and could be used by people with compromised immune systems. Dr. Raz also received support for this research from the National Institute of Diabetes and Digestive and Kidney Diseases, a part of the NIH. NIAID is a component of the National Institutes of Health (NIH), which is an agency of the Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose and treat infectious and immune- mediated illnesses, including HIV/AIDS and other sexually transmitted diseases, illness from potential agents of bioterrorism, tuberculosis, malaria, autoimmune disorders, asthma and allergies. Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov. REFERENCE: D Rachmilewitz et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. "Gastroenterology". (Feb. 2004) DOI:10.1053/j.gastro.2003.11.019.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™ FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map