ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Natural Remedies for the Prevention of Dry Eyes

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

CoQ10's Potential Capabilities for Your Health

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

Testosterone replacement therapy associated with improved urinary, sexual function

8 Chia Seed Recipes

 
Print Page
Email Article

Recognition of Bacteria in the Cytosol by the Immune System

  [ 45 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 3, 2004


In a finding that broadens our understanding of how the immune system can detect infection, researchers have identified a previously unappreciated way in which bacteria can be recognized inside our cells. Many bacteria cause disease by invading cells and creating a safe niche in which to replicate. Cells respond to the infection by activating the immune system, and a chief challenge for bacteria is to avoid immune detection. Prior research had shown that bacteria inside the cytosol (the cell's expansive gel-like compartment) could be detected, but how bacteria within the cytosol are recognized has not been clear. In the new work, Dr. John Brumell and colleagues at The Hospital for Sick Children studied the fate of Salmonella bacteria within the cytosol. These bacteria normally occupy vacuoles in host cells, but under some conditions they leave the vacuole and enter the cytosol. In this foreign environment, the bacteria were recognized by the ubiquitin system, a protein machine that applies molecular tags to cellular proteins to target them for destruction by the proteasome, essentially a molecular shredding device inside mammalian cells. These findings suggest that bacterial proteins are being destroyed by the proteasome within the cytosol during infection, and that this may play a key role in activation of the immune system. A surprising result came when Salmonella was compared with Listeria, a bacterium which normally occupies the cytosol. Listeria avoided recognition by the ubiquitin system by moving within this compartment. This suggests that Listeria and other bacteria that can colonize the cytosol do so in a manner that prevents activation of the immune system. Andrew J. Perrin, Xiuju Jiang, Cheryl L. Birmingham, Nancy S.Y. So, and John H. Brumell: "Recognition of Bacteria in the Cytosol of Mammalian Cells by the Ubiquitin System" Publishing in Current Biology, Volume 14, Number 9, May 4, 2004. Source: EurekAlert.org (this is a press release).



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
"It's Not Easy Being Green" - But It Is Healthy
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map