ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

CDC Whistleblower Reveals Widespread Manipulation of Scientific Data and Top-Down Pressure on CDC Sc...

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

9 Health Benefits of Cucumbers

How Glutathione Can Save Your Life

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

Antibiotics in early life may alter immunity long-term

New Research Helps Explain Why Elderly Are Prone to Sleep Problems

Brain inflammation dramatically disrupts memory retrieval networks, UCI study finds

VIDEO: Relaxation - Ocean Voyager Part I

Clinical trial demonstrates safety, effectiveness of immunotherapy for AdV, BKV, and herpesviruses i...

 
Print Page
Email Article

Common Painkillers Blunt Immune Response, New Research Indicates

  [ 1175 votes ]   [ Discuss This Article ]
By Editor • www.ProHealth.com • December 20, 2006


Using a common painkiller such as aspirin or ibuprofen (AdvilĀ®, MotrinĀ®, etc.) "might not be a good idea" around the time of a flu shot or other inoculation, according to a new report from vaccine researchers at the University of Rochester (New York). In particular, you probably should avoid taking one for pain at your injection site. These widely used drugs, known as NSAIDs (nonsteroidal anti-inflammatory drugs), appear to interfere with the body's immune response, and particularly with the intended production of antibodies after a vaccination.

The findings have "widespread implications," the researchers note, since from 50 to 70 percent of Americans use NSAIDs for pain and inflammation relief. (And usage is likely even higher among Fibromyalgia and Chronic Fatigue Syndrome patients.) The revelation may be particularly important for older people, who are often heavy users of NSAIDs, and tend to be poor responders to flu and other vaccinations, says lead researcher Richard P. Phipps, PhD, a professor of Microbiology and Immunology. "This study could help explain the immune response problem," he notes.

NSAIDs Inhibit More Than Cox-2
NSAIDs are also known as "cox-2 inhibitors." The cyclooxygenase-2 (cox-2) enzyme acts to support repair of damage done by infection, a process that involves some degree of fever and inflammation (potentially pain). And the cox-2 inhibiting drugs blunt this response.

However, in studying the blood of subjects vaccinated during testing of the new HPV (Human Papillomavirus) vaccine to prevent cervical cancer, the investigators discovered that the cox-2 enzyme also influences the activity of human B-lymphocytes (B-cells) - the type of white blood cell that springs into action to produce antibodies when we're vaccinated. These "B-cells" work both to neutralize invading viral agents and produce memories of them for future recognition and response. The blood of vaccinated subjects produced a rich supply of antibodies to the HPV virus. But when cox-2 inhibitors were introduced to the subjects' blood, the B-cells' ability to produce antibodies was severely reduced.

The researchers produced a similar finding by testing relationship between cox-2 expression and B-cell antibody production in animals. Two groups of mice were vaccinated - one group that had been engineered to be cox-2 deficient and one normal control group. The cox-2 deficient animals made 50 to 70 percent fewer antibodies than the normal control animals.

Implications for the Immune Compromised?
The scientists say they don't yet understand exactly how cox-2 influences immune response. And while they emphasize they're not questioning the HPV vaccine, which proved effective in many trials even though some subjects undoubtedly had taken NSAIDs, they believe the extent of immune response generally "may depend upon the dose and frequency of NSAID use." They suggest that "the negative effects of blocking cox-2 could be more pronounced in people with compromised immune systems," and in situations where lower-than-optimal doses are administered when vaccines are in short supply.

The study report, "Cyclooxygenase-2 Inhibition Attenuates Antibody Responses Against Human Papillomavirus-Like Particles," by EP Ryan, et al., was published in the December 1, 2006 issue of The Journal of Immunology http://www.jimmunol.org/cgi/content/abstract/177/11/7811

Note: This information has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. It is extremely important that you make no change in your health support plan or regimen without careful review and collaborative consideration with your professional healthcare team.



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamin B-12

Featured Products

FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

How I Found My Long-Lost Energy How I Found My Long-Lost Energy
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing