ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

List of diseases spread by deer tick grows, including malaria-like problems and potentially fatal en...

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

Lyme disease confirmed in humans from southern states

The Worst Foods to Eat When You're Sick, and the Best Ones

Teenager with stroke symptoms actually had Lyme disease

The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from do...

World Famous Joint Relief Formula Enhanced by Modern Science

Scientists Reveal Quirky Feature of Lyme Disease Bacteria

Mayo Clinic Study of Thousands of Brains Reveals Tau as Driver of Alzheimer’s Disease

In a warmer world, ticks that spread disease are arriving earlier, expanding their ranges

 
Print Page
Email Article

Common Painkillers Blunt Immune Response, New Research Indicates

  [ 1175 votes ]   [ Discuss This Article ]
By Editor • www.ProHealth.com • December 20, 2006


Using a common painkiller such as aspirin or ibuprofen (Advil®, Motrin®, etc.) "might not be a good idea" around the time of a flu shot or other inoculation, according to a new report from vaccine researchers at the University of Rochester (New York). In particular, you probably should avoid taking one for pain at your injection site. These widely used drugs, known as NSAIDs (nonsteroidal anti-inflammatory drugs), appear to interfere with the body's immune response, and particularly with the intended production of antibodies after a vaccination.

The findings have "widespread implications," the researchers note, since from 50 to 70 percent of Americans use NSAIDs for pain and inflammation relief. (And usage is likely even higher among Fibromyalgia and Chronic Fatigue Syndrome patients.) The revelation may be particularly important for older people, who are often heavy users of NSAIDs, and tend to be poor responders to flu and other vaccinations, says lead researcher Richard P. Phipps, PhD, a professor of Microbiology and Immunology. "This study could help explain the immune response problem," he notes.

NSAIDs Inhibit More Than Cox-2
NSAIDs are also known as "cox-2 inhibitors." The cyclooxygenase-2 (cox-2) enzyme acts to support repair of damage done by infection, a process that involves some degree of fever and inflammation (potentially pain). And the cox-2 inhibiting drugs blunt this response.

However, in studying the blood of subjects vaccinated during testing of the new HPV (Human Papillomavirus) vaccine to prevent cervical cancer, the investigators discovered that the cox-2 enzyme also influences the activity of human B-lymphocytes (B-cells) - the type of white blood cell that springs into action to produce antibodies when we're vaccinated. These "B-cells" work both to neutralize invading viral agents and produce memories of them for future recognition and response. The blood of vaccinated subjects produced a rich supply of antibodies to the HPV virus. But when cox-2 inhibitors were introduced to the subjects' blood, the B-cells' ability to produce antibodies was severely reduced.

The researchers produced a similar finding by testing relationship between cox-2 expression and B-cell antibody production in animals. Two groups of mice were vaccinated - one group that had been engineered to be cox-2 deficient and one normal control group. The cox-2 deficient animals made 50 to 70 percent fewer antibodies than the normal control animals.

Implications for the Immune Compromised?
The scientists say they don't yet understand exactly how cox-2 influences immune response. And while they emphasize they're not questioning the HPV vaccine, which proved effective in many trials even though some subjects undoubtedly had taken NSAIDs, they believe the extent of immune response generally "may depend upon the dose and frequency of NSAID use." They suggest that "the negative effects of blocking cox-2 could be more pronounced in people with compromised immune systems," and in situations where lower-than-optimal doses are administered when vaccines are in short supply.

The study report, "Cyclooxygenase-2 Inhibition Attenuates Antibody Responses Against Human Papillomavirus-Like Particles," by EP Ryan, et al., was published in the December 1, 2006 issue of The Journal of Immunology http://www.jimmunol.org/cgi/content/abstract/177/11/7811

Note: This information has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. It is extremely important that you make no change in your health support plan or regimen without careful review and collaborative consideration with your professional healthcare team.



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing