ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

Amyloid-B-Induced Pathological Behaviors Are Suppressed by Ginkgo biloba Extract EGb 761 and Ginkgolides in Transgenic Caenorhabditis elegans

  [ 364 votes ]   [ Discuss This Article ]
By Y Wu, et al • www.ProHealth.com • January 31, 2007


[Note: Amyloid beta is the main constituent of amyloid plaques in the brains of Alzheimer’s patients. Study concludes component of Ginkgo biloba extract “has therapeutic potential for prevention and treatment of Alzheimer’s disease.”]

Journal: The Journal of Neuroscience. December 13, 2006. 26(50); 13102-13113. [E-publication ahead of print]

Authors and affiliations: Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland (Y Wu, Luo); Departments of Biological Sciences (Z Wu) and Chemistry and Biochemistry (Butko), University of Southern Mississippi, Hattiesburg, Mississippi; Ipsen, Paris, France (Christen); Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois (Lambert, Klein); Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado (Link). [E-mail: yluo@rx.umaryland.edu ]

DOI:10.1523/JNEUROSCI.3448-06.2006

Amyloid-B (AB) toxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration seen in Alzheimer's disease (AD).

We previously demonstrated that the standardized Ginkgo biloba extract EGb 761, commonly used to enhance memory and by Alzheimer’s disease patients for dementia, inhibits AB-induced apoptosis in neuroblastoma cells.

In this study, we use Ginkgo biloba extract EGb 761 and its single constituents to associate AB species with Amyloid-B-induced pathological behaviors in a model organism, Caenorhabditis elegans.

We report that Ginkgo biloba extract EGb 761 and one of its components, ginkgolide A, alleviates AB-induced pathological behaviors, including paralysis, and reduces chemotaxis behavior and 5-HT hypersensitivity in a transgenic C. elegans.

We also show that Ginkgo biloba extract EGb 761 inhibits AB oligomerization and AB deposits in the worms. Moreover, reducing oxidative stress is not the mechanism by which EGb 761 and ginkgolide A suppress AB-induced paralysis because the antioxidant L-ascorbic acid reduced intracellular levels of hydrogen peroxide to the same extent as EGb 761, but was not nearly as effective in suppressing paralysis in the transgenic C. elegans.

These findings suggest that:
1. Ginkgo biloba extract EGb 761 suppresses AB-related pathological behaviors,
2. The protection against AB toxicity by EGb 761 is mediated primarily by modulating AB oligomeric species, and
3. Ginkgolide A [a component of Ginkgo biloba extract EGb 761] has therapeutic potential for prevention and treatment of Alzheimer’s disease.

Key words: AB peptide, Alzheimer's disease, behavior, mutant, phenotype, serotonin





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map