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Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

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By F Van Den Eede, et al. • • June 30, 2007

[Note: the HPA axis is "the control center of most of the body's hormonal systems."]

Journal: Neuropsychobiology. 2007 Jun 27;55(2):112-120 [E-publication ahead of print]

Authors and affiliation: Van Den Eede F, Moorkens G, Van Houdenhove B, Cosyns P, Claes SJ. Department of Psychiatry, University Hospital Antwerp, Edegem, Belgium.

PMID: 17596739

There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with Chronic Fatigue Syndrome (CFS), despite the negative studies and methodological difficulties. In this review, we focus on challenge studies and on the role of the HPA axis in the pathogenesis of CFS.

Mild hypocortisolism, blunted adrenocorticotropin response to stressors and enhanced negative feedback sensitivity to glucocorticoids are the main findings.

Several underlying mechanisms have been proposed. Currently, it is a matter of debate whether these disturbances have a primary role in the pathogenesis of CFS.

However, even if the HPA axis dysfunctions are secondary to other factors, they are probably a relevant factor in symptom propagation in CFS.

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