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The biochemical origin of pain: The origin of all pain is inflammation and the inflammatory response. Part 2 of 3 - Inflammatory profile of pain syndromes

  [ 136 votes ]   [ 2 Comments ]
By S Omoigui • • September 5, 2007

Every pain syndrome has an inflammatory profile consisting of the inflammatory mediators that are present in the pain syndrome. The inflammatory profile may have variations from one person to another and may have variations in the same person at different times. The key to treatment of Pain Syndromes is an understanding of their inflammatory profile.

Pain syndromes may be treated medically or surgically. The goal should be inhibition or suppression of production of the inflammatory mediators and inhibition, suppression or modulation of neuronal afferent and efferent (motor) transmission. A successful outcome is one that results in less inflammation and thus less pain.

We hereby briefly describe the inflammatory profile for several pain syndromes including arthritis, back pain, neck pain, Fibromyalgia, interstitial cystitis, migraine, neuropathic pain, complex regional pain syndrome/reflex sympathetic dystrophy (CRPS/RSD), bursitis, shoulder pain and vulvodynia.

These profiles are derived from basic science and clinical research performed in the past by numerous investigators and serve as a Foundation to be built upon by other researchers and will be updated in the future by new technologies such as magnetic resonance spectroscopy.

Our unifying theory or law of pain states: the origin of all pain is inflammation and the inflammatory response. The biochemical mediators of inflammation include cytokines, neuropeptides, growth factors and neurotransmitters. Irrespective of the type of pain whether it is acute or chronic pain, peripheral or central pain, nociceptive or neuropathic pain, the underlying origin is inflammation and the inflammatory response.

Activation of pain receptors, transmission and modulation of pain signals, neuro plasticity and central sensitization are all one continuum of inflammation and the inflammatory response. Irrespective of the characteristic of the pain, whether it is sharp, dull, aching, burning, stabbing, numbing or tingling, all pain arises from inflammation and the inflammatory response.

We are proposing a re-classification and treatment of pain syndromes based upon their inflammatory profile.

Source: Medical Hypotheses. 2007 Aug 27; [E-publication ahead of print] PMID: 17728071, by Omoigui S. Division of Inflammation and Pain Research, L.A. Pain Clinic, Los Angeles, California, USA. [ E-mail: ] See also: "The biochemical origin of pain: proposing a new law of pain: The origin of all pain is inflammation and the inflammatory response. Part 1 of 3 - a unifying law of pain"

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Article Comments Post a Comment

Part 2 of an erroneous article
Posted by: moonrose777
Sep 12, 2007
All the newest research is showing no inflammatory process involved in fibro. We do not run fevers indicating inflammation is present. We don't have redness or swelling at the site of pain. Fibro is clearly an malfunction of neuro receptors, not inflammation, or in other words, either a chemical or functional error in the brain. Printing articles like this are not in the best interest of those of us who are trying to manage our illness. We need to know that articles supplied to us are accurate so that we don't look like complete idiots when taking information to our medical professional. Trying to control Fibro with anti-inflammatories is a part of the dark ages of understanding this illness. It didn't work then and won't work now. I was seeking pain relief before fibro had a name and had everything in the PDR thrown at it. Do we have to go back to those days and start again? I sure hope not.
Reply Reply

Fibromyalgia - inflammatory process????
Posted by: dwink
Sep 15, 2007
I would have to agree with moonrose, when I was diagnosed with this dreadful disease in 1987 it was still called, by some, "Fibrositis", but was just being changed to "Fibromyalgia", because, fibromyalgia does not have inflammation in it's list of symptoms. And, I have heard and read this all these years that it does not cause or have inflammation. Oddly enough, doctors are now using a diagnosis of "Myalgia and Myositis". I am confused, and I am sure a lot of other people with FMS are confused, as well. This diagnosis means again, pain and inflammation in the muscle. Now, I am NOT a doctor or nurse, but I do have Fibromyalgia and I have suffered alot and read a lot. I'm beginning to think you really should only believe 50% of what you read and half of what you hear. I'm just waiting for the day they all get together on the same page. Take care.


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